HCSGD entry for INPP5K

1. General information

Official gene symbolINPP5K
Entrez ID51763
Gene full nameinositol polyphosphate-5-phosphatase K
Other gene symbolsPPS SKIP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001726RuffleIDAcellular_component
GO:0001933Negative regulation of protein phosphorylationISSbiological_process
GO:0004445Inositol-polyphosphate 5-phosphatase activityIEAmolecular_function
GO:0005000Vasopressin receptor activityIEA ISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIEA ISScellular_component
GO:0005783Endoplasmic reticulumIDAcellular_component
GO:0005802Trans-Golgi networkIDAcellular_component
GO:0005829CytosolIDA TAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005979Regulation of glycogen biosynthetic processISSbiological_process
GO:0006469Negative regulation of protein kinase activityIDAbiological_process
GO:0006644Phospholipid metabolic processTASbiological_process
GO:0006661Phosphatidylinositol biosynthetic processTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayISSbiological_process
GO:0008152Metabolic processIDAbiological_process
GO:0010801Negative regulation of peptidyl-threonine phosphorylationIDAbiological_process
GO:0010829Negative regulation of glucose transportIDAbiological_process
GO:0016020MembraneIDAcellular_component
GO:0016311DephosphorylationIDA IMPbiological_process
GO:0016312Inositol bisphosphate phosphatase activityIDAmolecular_function
GO:0030036Actin cytoskeleton organizationNASbiological_process
GO:0032587Ruffle membraneIDAcellular_component
GO:0032868Response to insulinIEAbiological_process
GO:0032869Cellular response to insulin stimulusIDAbiological_process
GO:0032870Cellular response to hormone stimulusIEA ISSbiological_process
GO:0033137Negative regulation of peptidyl-serine phosphorylationIDA IEAbiological_process
GO:0034485Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activityIDA IEAmolecular_function
GO:0034594Phosphatidylinositol trisphosphate phosphatase activityIDAmolecular_function
GO:0034595Phosphatidylinositol phosphate 5-phosphatase activityIMPmolecular_function
GO:0035305Negative regulation of dephosphorylationIEA ISSbiological_process
GO:0035810Positive regulation of urine volumeIEA ISSbiological_process
GO:0042577Lipid phosphatase activityNASmolecular_function
GO:0042593Glucose homeostasisIEA ISSbiological_process
GO:0043005Neuron projectionIDAcellular_component
GO:0043407Negative regulation of MAP kinase activityIDAbiological_process
GO:0043922Negative regulation by host of viral transcriptionIDAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045719Negative regulation of glycogen biosynthetic processIDA IEAbiological_process
GO:0045869Negative regulation of single stranded viral RNA replication via double stranded DNA intermediateIDAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIEA ISSbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIEA ISSbiological_process
GO:0046030Inositol trisphosphate phosphatase activityIDAmolecular_function
GO:0046627Negative regulation of insulin receptor signaling pathwayIDA IEAbiological_process
GO:0046855Inositol phosphate dephosphorylationIDAbiological_process
GO:0046856Phosphatidylinositol dephosphorylationIDA IEAbiological_process
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0051497Negative regulation of stress fiber assemblyIDAbiological_process
GO:0051898Negative regulation of protein kinase B signalingIDA IEAbiological_process
GO:0051926Negative regulation of calcium ion transportIDAbiological_process
GO:0052658Inositol-1,4,5-trisphosphate 5-phosphatase activityIEAmolecular_function
GO:0052659Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activityIEAmolecular_function
GO:0071320Cellular response to cAMPIEA ISSbiological_process
GO:0071356Cellular response to tumor necrosis factorIDAbiological_process
GO:0071364Cellular response to epidermal growth factor stimulusIDAbiological_process
GO:0072661Protein targeting to plasma membraneIEA ISSbiological_process
GO:0090315Negative regulation of protein targeting to membraneIDAbiological_process
GO:0097178Ruffle assemblyIDAbiological_process
GO:2000466Negative regulation of glycogen (starch) synthase activityIEA ISSbiological_process
GO:2001153Positive regulation of renal water transportIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.30683747960.30473868770.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2460727952
GSE13712_SHEARDown-0.8468219522
GSE13712_STATICDown-0.2946546346
GSE19018Up0.1009526135
GSE19899_A1Down-0.2664676319
GSE19899_A2Up0.2955977086
PubMed_21979375_A1Down-0.2447915306
PubMed_21979375_A2Up0.3687763499
GSE35957Up0.5117531560
GSE36640Up0.2753084994
GSE54402Down-0.0267132822
GSE9593Up0.4872262944
GSE43922Up0.1301609395
GSE24585Up0.0092811514
GSE37065Down-0.2763924355
GSE28863_A1Down-0.0905434846
GSE28863_A2Down-0.5212377644
GSE28863_A3Down-0.3221842567
GSE28863_A4Up0.0436225052
GSE48662Up0.4838059340

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT029506MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.