HCSGD entry for SERPINF1
1. General information
| Official gene symbol | SERPINF1 |
|---|---|
| Entrez ID | 5176 |
| Gene full name | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 |
| Other gene symbols | EPC-1 OI12 OI6 PEDF |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001822 | Kidney development | IEA | biological_process |
| GO:0004867 | Serine-type endopeptidase inhibitor activity | IBA | molecular_function |
| GO:0005576 | Extracellular region | IDA | cellular_component |
| GO:0005615 | Extracellular space | IDA IEA | cellular_component |
| GO:0007275 | Multicellular organismal development | TAS | biological_process |
| GO:0007568 | Aging | IEA | biological_process |
| GO:0007614 | Short-term memory | IEA | biological_process |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0010951 | Negative regulation of endopeptidase activity | IBA | biological_process |
| GO:0016525 | Negative regulation of angiogenesis | IDA | biological_process |
| GO:0030162 | Regulation of proteolysis | IBA | biological_process |
| GO:0031012 | Extracellular matrix | IDA | cellular_component |
| GO:0032526 | Response to retinoic acid | IEA | biological_process |
| GO:0042470 | Melanosome | IEA | cellular_component |
| GO:0050728 | Negative regulation of inflammatory response | IEA | biological_process |
| GO:0050769 | Positive regulation of neurogenesis | IDA | biological_process |
| GO:0051384 | Response to glucocorticoid | IEA | biological_process |
| GO:0060770 | Negative regulation of epithelial cell proliferation involved in prostate gland development | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1173092094 | 0.0003005509 | 0.7023364939 | 0.0316432000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0173205426 |
| GSE13712_SHEAR | Down | -0.0233354741 |
| GSE13712_STATIC | Up | 0.0391605844 |
| GSE19018 | Down | -2.7822831215 |
| GSE19899_A1 | Down | -0.8689335448 |
| GSE19899_A2 | Down | -3.7374635673 |
| PubMed_21979375_A1 | Down | -2.3185483542 |
| PubMed_21979375_A2 | Down | -3.9842264586 |
| GSE35957 | Down | -0.4278064096 |
| GSE36640 | Down | -3.4847406496 |
| GSE54402 | Down | -1.9382913383 |
| GSE9593 | Down | -0.0009365967 |
| GSE43922 | Down | -1.4726730604 |
| GSE24585 | Up | 1.2455183351 |
| GSE37065 | Down | -0.1281829480 |
| GSE28863_A1 | Up | 1.6194272328 |
| GSE28863_A2 | Up | 0.7871948250 |
| GSE28863_A3 | Up | 0.4249688331 |
| GSE28863_A4 | Up | 0.0138819093 |
| GSE48662 | Down | -0.4694372600 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017228 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 11 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23359450 | Thus we hypothesized that PEDF could delay senescence during MSC expansion by reducing oxidative stress |
| 23359450 | In MSCs cultured under normoxic conditions treated with PEDF, proliferative lifespan in vitro was significantly increased compared with control group not given PEDF, with approximately 10 additional population doublings (PD) occurring before terminal growth arrest |
| 23359450 | PEDF also preserved differentiation potentials of MSCs compared with the control group |
| 23359450 | Thus PEDF suppression of oxidative stress delays cellular senescence and allows greater expansion of MSCs |
| 18060755 | Also, DHA and PEDF synergistically activate NPD1 synthesis and antiapoptotic protein expression and decreased proapoptotic Bcl-2 protein expression and caspase 3 activation during oxidative stress |
| 16896539 | Early population doubling cDNA-1 (EPC-1, also known as pigment epithelial derived factor, PEDF) is one of the genes whose expression decreases dramatically during cellular aging |
| 16896539 | We examined whether or not EPC-1/PEDF promoter activity was affected by the cellular ageing using human diploid lung fibroblast cells in culture |
| 16896539 | Here we showed the promoter/enhancer region of EPC-1/PEDF existed at more than 1760 bp upstream from the transcriptional initiation site of the gene, and was regulated by both aging and cell cycle |
| 16896539 | These findings suggest that the expression of the EPC-1/PEDF gene is, at least in part, regulated transcriptionally in the cells |
| 16896539 | The analysis of the promoter region of the EPC-1/PEDF gene in this paper suggests the age- and cell cycle-dependent expression of specific transcriptional factor(s) |
| 16523493 | The results also indicate that inhibition of the proteasome in young cells induces a premature senescent-like phenotype, as indicated by the increase in senescence-associated beta-galactosidase (SA beta-gal) activity and the abundance of both p21 and collagenase mRNAs, as well as a decreased level of EPC-1 mRNA known markers of cellular senescence, not previously shown to depend on proteasome activity |
| 12599204 | Putative role for EPC-1/PEDF in the G0 growth arrest of human diploid fibroblasts |
| 12599204 | EPC-1/PEDF expression is closely associated with reversible growth arrest in normal human diploid fibroblast-like (HDF) cells and is diminished with proliferative senescence in vitro |
| 12599204 | EPC-1 expression in HDF cells is induced under conditions of density-dependent contact inhibition and growth factor deprivation |
| 12599204 | Antiserum generated against EPC-1 recognizes a secreted protein of approximately 50 kDa from medium conditioned by early passage HDF cells, but not from senescent cells |
| 12599204 | The addition of EPC-1 antiserum to early population doubling level (PDL) cultures near the plateau phase of growth significantly increases the number of cells entering DNA synthesis |
| 12599204 | Affinity purified EPC-1 antibodies alone enhance the ability of near plateau-phase early PDL WI-38 cells to synthesize DNA by as much as threefold |
| 12599204 | Further, the addition of recombinant EPC-1 (rEPC-1) to logarithmically growing cells resulted in a marked decrease in the ability of these cells to enter DNA synthesis |
| 12599204 | We also demonstrate the loss of EPC-1 expression in WI-38 and IMR-90 HDF cell lines with both senescence and simian virus 40 (SV40) transformation |
| 12599204 | Taken together, these results suggest that EPC-1 may play a role in the entry of early passage fibroblasts into a G(0) state or the maintenance of such a state once reached |
| 12530532 | The determination of a high resolution X-ray crystal structure of native PEDF provides insight into regions of the protein that may be involved in one or more of these functions |
| 10784448 | Early population doubling level complementary DNA-1 (EPC-1, an age-dependent gene) expression in cells from the cloned animals was 3 |
| 10576245 | Both the NUV-irradiated RPE cells and RPE cells at 20 Pd expressed 4 to 8-fold and 2 to 4-fold less PEDF and TIMP-3 genes, respectively |
| 9426047 | The specific phenotypic changes seen following inhibition of PI-3 kinase are: an increase in beta-galactosidase activity; a decrease in EPC-1 gene expression; and a dramatic increase in collagenase gene expression |
| 7664833 | A comparison of secreted proteins revealed the senescence-specific absence of all forms of EPC-1, a protein associated with early PDL cells in the G0 state |
| 1279330 | Two genes, EPC-1 and EPC-A2, with elevated RNA levels in young cells, have sequences which have not previously been identified |
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