HCSGD entry for CDK12
1. General information
| Official gene symbol | CDK12 |
|---|---|
| Entrez ID | 51755 |
| Gene full name | cyclin-dependent kinase 12 |
| Other gene symbols | CRK7 CRKR CRKRS hCDK12 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002944 | Cyclin K-CDK12 complex | IPI | cellular_component |
| GO:0004672 | Protein kinase activity | IDA | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0004693 | Cyclin-dependent protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006397 | MRNA processing | IEA | biological_process |
| GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity | IMP | molecular_function |
| GO:0008380 | RNA splicing | ISS | biological_process |
| GO:0016607 | Nuclear speck | IDA | cellular_component |
| GO:0019908 | Nuclear cyclin-dependent protein kinase holoenzyme complex | ISS | cellular_component |
| GO:0030332 | Cyclin binding | IPI | molecular_function |
| GO:0043405 | Regulation of MAP kinase activity | IMP | biological_process |
| GO:0046777 | Protein autophosphorylation | IDA | biological_process |
| GO:0070816 | Phosphorylation of RNA polymerase II C-terminal domain | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1185846472 | 0.9118707192 | 0.7063136878 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0330000752 |
| GSE13712_SHEAR | Up | 0.3158409388 |
| GSE13712_STATIC | Up | 0.1032390846 |
| GSE19018 | Down | -0.2395143468 |
| GSE19899_A1 | Up | 0.2247420839 |
| GSE19899_A2 | Up | 0.1079985056 |
| PubMed_21979375_A1 | Down | -0.2468146032 |
| PubMed_21979375_A2 | Up | 0.4721428699 |
| GSE35957 | Up | 0.0858158323 |
| GSE36640 | Up | 0.2996852404 |
| GSE54402 | Up | 0.1734760918 |
| GSE9593 | Down | -0.0909995712 |
| GSE43922 | Up | 0.1452370707 |
| GSE24585 | Down | -0.2227624360 |
| GSE37065 | Up | 0.0511984274 |
| GSE28863_A1 | Up | 0.8168901688 |
| GSE28863_A2 | Up | 0.5166100287 |
| GSE28863_A3 | Down | -0.0794599511 |
| GSE28863_A4 | Up | 0.1327278212 |
| GSE48662 | Down | -0.3157354389 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-744-5p | MIMAT0004945 | MIRT037446 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-503-5p | MIMAT0002874 | MIRT041108 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041547 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193a-3p | MIMAT0000459 | MIRT044886 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10b-5p | MIMAT0000254 | MIRT047459 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
