HCSGD entry for ERAP1

1. General information

Official gene symbolERAP1
Entrez ID51752
Gene full nameendoplasmic reticulum aminopeptidase 1
Other gene symbolsA-LAP ALAP APPILS ARTS-1 ARTS1 ERAAP ERAAP1 PILS-AP PILSAP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001525AngiogenesisTASbiological_process
GO:0002474Antigen processing and presentation of peptide antigen via MHC class ITASbiological_process
GO:0004177Aminopeptidase activityIDAmolecular_function
GO:0005138Interleukin-6 receptor bindingIPImolecular_function
GO:0005151Interleukin-1, Type II receptor bindingTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIDAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0005783Endoplasmic reticulumNAScellular_component
GO:0005788Endoplasmic reticulum lumenTAScellular_component
GO:0005789Endoplasmic reticulum membraneIEAcellular_component
GO:0005829CytosolNAScellular_component
GO:0006508ProteolysisIEAbiological_process
GO:0006509Membrane protein ectodomain proteolysisIDAbiological_process
GO:0008217Regulation of blood pressureNAS TASbiological_process
GO:0008235Metalloexopeptidase activityIDAmolecular_function
GO:0008237Metallopeptidase activityIEAmolecular_function
GO:0008270Zinc ion bindingIEA NASmolecular_function
GO:0009617Response to bacteriumIEPbiological_process
GO:0016021Integral component of membraneNAScellular_component
GO:0019885Antigen processing and presentation of endogenous peptide antigen via MHC class INAS TASbiological_process
GO:0045088Regulation of innate immune responseNASbiological_process
GO:0045444Fat cell differentiationNASbiological_process
GO:0045766Positive regulation of angiogenesisIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.51888001980.01199533450.99999024730.2164006152

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2507924498
GSE13712_SHEARDown-0.1745017719
GSE13712_STATICUp0.1800905022
GSE19018Up0.1047714449
GSE19899_A1Down-0.7322818772
GSE19899_A2Down-1.3800532579
PubMed_21979375_A1Down-0.7273945606
PubMed_21979375_A2Down-1.4746235223
GSE35957Down-0.6979929505
GSE36640Up0.5921551777
GSE54402Down-0.6259426632
GSE9593Down-0.0558457073
GSE43922Down-1.4992452436
GSE24585Up0.5589156689
GSE37065Up0.2139366105
GSE28863_A1Up0.7087819898
GSE28863_A2Up0.5003261796
GSE28863_A3Down-0.5327680428
GSE28863_A4Down-0.2338807685
GSE48662Up0.1247468799

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT019189MicroarrayFunctional MTI (Weak)18185580
hsa-miR-26b-5pMIMAT0000083MIRT030332MicroarrayFunctional MTI (Weak)19088304
hsa-miR-92a-3pMIMAT0000092MIRT049298CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

11781307The data imply that the ERalpha-AP1 pathway activated by oncogenic K-Ras 4B mutant contributes to the NIH3T3 cells' transformation by modulating p53 transcriptional activity through MDM2
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