HCSGD entry for WWOX

1. General information

Official gene symbolWWOX
Entrez ID51741
Gene full nameWW domain containing oxidoreductase
Other gene symbolsD16S432E FOR FRA16D HHCMA56 PRO0128 SDR41C1 WOX1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001649Osteoblast differentiationIEAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDA TAScellular_component
GO:0005739MitochondrionISScellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005829CytosolIDA TAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005902MicrovillusIDAcellular_component
GO:0008202Steroid metabolic processTASbiological_process
GO:0016055Wnt signaling pathwayIEAbiological_process
GO:0016491Oxidoreductase activityNAS TASmolecular_function
GO:0019899Enzyme bindingIPImolecular_function
GO:0030178Negative regulation of Wnt signaling pathwayIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0046983Protein dimerization activityTASmolecular_function
GO:0048037Cofactor bindingTASmolecular_function
GO:0048705Skeletal system morphogenesisISSbiological_process
GO:0050662Coenzyme bindingTASmolecular_function
GO:0055114Oxidation-reduction processTASbiological_process
GO:0071560Cellular response to transforming growth factor beta stimulusIDAbiological_process
GO:0072332Intrinsic apoptotic signaling pathway by p53 class mediatorIEAbiological_process
GO:0097191Extrinsic apoptotic signaling pathwayIEAbiological_process
GO:2001238Positive regulation of extrinsic apoptotic signaling pathwayISSbiological_process
GO:2001241Positive regulation of extrinsic apoptotic signaling pathway in absence of ligandIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.53693482010.80882773450.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0247619406
GSE13712_SHEARDown-0.4829987770
GSE13712_STATICDown-0.2912391766
GSE19018Down-0.0941507007
GSE19899_A1Up0.0573223877
GSE19899_A2Up0.0706609635
PubMed_21979375_A1Up0.0156398232
PubMed_21979375_A2Up0.2392215737
GSE35957Down-0.0074755389
GSE36640Up0.2892046149
GSE54402Down-0.0173013126
GSE9593Up0.3231673519
GSE43922Up0.0536730014
GSE24585Down-0.1471794872
GSE37065Up0.0355764853
GSE28863_A1Up0.3046143083
GSE28863_A2Up0.0397774786
GSE28863_A3Up0.1490238125
GSE28863_A4Up0.0716224849
GSE48662Down-0.0660513186

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

21212468Zfra (zinc finger-like protein that regulates apoptosis) is a naturally occurring short peptide consisting of 31 amino acids, which regulates tumor necrosis factor (TNF)-mediated cell death by interacting with receptor adaptor protein TRADD (TNF receptorassociated death domain protein) and downstream JNK (c-Jun N-terminal kinase), NF-kappaB (Nuclear factor kappa B) and WWOX/WOX1 (WW domain-containing oxidoreductase)
21212468Remarkably, overexpressed Zfra induces apoptosis via the mitochondrial pathway, which involves suppression of Bcl-2 and Bcl-xL expression (without causing cytochrome c release), counteracting the apoptotic function of tumor suppressor p53 and WWOX, and dissipation of mitochondrial membrane potential for ultimately leading to cell death
21212468Control of cellular aging and apoptosis by Zfra, p53 and WWOX is discussed
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