HCSGD entry for GHRL

1. General information

Official gene symbol	GHRL
Entrez ID	51738
Gene full name	ghrelin/obestatin prepropeptide
Other gene symbols	MTLRP
Links to Entrez Gene	Links to Entrez Gene

2. Neighbors in the network

This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID	GO term	Evidence	Category
GO:0000187	Activation of MAPK activity	IMP	biological_process
GO:0001664	G-protein coupled receptor binding	ISS	molecular_function
GO:0001696	Gastric acid secretion	IEA	biological_process
GO:0001937	Negative regulation of endothelial cell proliferation	IDA	biological_process
GO:0005576	Extracellular region	IDA IEA TAS	cellular_component
GO:0005615	Extracellular space	IDA	cellular_component
GO:0005737	Cytoplasm	IEA	cellular_component
GO:0005788	Endoplasmic reticulum lumen	TAS	cellular_component
GO:0006006	Glucose metabolic process	NAS	biological_process
GO:0007186	G-protein coupled receptor signaling pathway	IEA ISS TAS	biological_process
GO:0007204	Positive regulation of cytosolic calcium ion concentration	IEA ISS	biological_process
GO:0008154	Actin polymerization or depolymerization	IDA	biological_process
GO:0008343	Adult feeding behavior	IEA ISS	biological_process
GO:0009725	Response to hormone	IDA	biological_process
GO:0009755	Hormone-mediated signaling pathway	TAS	biological_process
GO:0016358	Dendrite development	IDA	biological_process
GO:0016525	Negative regulation of angiogenesis	NAS	biological_process
GO:0016608	Growth hormone-releasing hormone activity	IEA ISS TAS	molecular_function
GO:0030252	Growth hormone secretion	TAS	biological_process
GO:0030296	Protein tyrosine kinase activator activity	IMP	molecular_function
GO:0030424	Axon	IDA	cellular_component
GO:0031768	Ghrelin receptor binding	IEA ISS TAS	molecular_function
GO:0032024	Positive regulation of insulin secretion	IEA ISS	biological_process
GO:0032100	Positive regulation of appetite	IEA ISS	biological_process
GO:0032691	Negative regulation of interleukin-1 beta production	IDA	biological_process
GO:0034774	Secretory granule lumen	TAS	cellular_component
GO:0040013	Negative regulation of locomotion	IEA	biological_process
GO:0040018	Positive regulation of multicellular organism growth	IC	biological_process
GO:0042127	Regulation of cell proliferation	IDA	biological_process
GO:0042322	Negative regulation of circadian sleep/wake cycle, REM sleep	IDA	biological_process
GO:0042536	Negative regulation of tumor necrosis factor biosynthetic process	IDA	biological_process
GO:0043066	Negative regulation of apoptotic process	IDA	biological_process
GO:0043400	Cortisol secretion	NAS	biological_process
GO:0043627	Response to estrogen	IDA	biological_process
GO:0044267	Cellular protein metabolic process	TAS	biological_process
GO:0045409	Negative regulation of interleukin-6 biosynthetic process	IDA	biological_process
GO:0046010	Positive regulation of circadian sleep/wake cycle, non-REM sleep	IDA	biological_process
GO:0046676	Negative regulation of insulin secretion	IEA	biological_process
GO:0046697	Decidualization	IDA	biological_process
GO:0050728	Negative regulation of inflammatory response	IDA	biological_process
GO:0051216	Cartilage development	NAS	biological_process
GO:0051461	Positive regulation of corticotropin secretion	IDA	biological_process
GO:0051464	Positive regulation of cortisol secretion	IDA	biological_process
GO:0051965	Positive regulation of synapse assembly	IDA	biological_process
GO:0060079	Regulation of excitatory postsynaptic membrane potential	IEA	biological_process
GO:0060124	Positive regulation of growth hormone secretion	IDA	biological_process
GO:0060399	Positive regulation of growth hormone receptor signaling pathway	IC	biological_process
GO:0061098	Positive regulation of protein tyrosine kinase activity	IMP	biological_process

Entries Per Page

Displaying Page of

4. Expression levels in datasets

Meta-analysis result

p-value up	p-value down	FDR up	FDR down
0.6279238365	0.8514439953	0.9999902473	1.0000000000

Individual experiment result
( "-" represent NA in the specific microarray platform )

Data source	Up or down	Log fold change
GSE11954	Down	-0.0545299107
GSE13712_SHEAR	Up	0.1160631321
GSE13712_STATIC	Down	-0.0716106572
GSE19018	Up	0.2018152390
GSE19899_A1	Up	0.1207931146
GSE19899_A2	Up	0.0818592225
PubMed_21979375_A1	Up	0.1498201700
PubMed_21979375_A2	Up	0.0294174888
GSE35957	Up	0.0482114393
GSE36640	Down	-0.0371387305
GSE54402	Up	0.1582792059
GSE9593	Down	-0.0377876834
GSE43922	Up	0.0620958840
GSE24585	Down	-0.0539982257
GSE37065	Down	-0.0388057936
GSE28863_A1	Down	-0.1292338886
GSE28863_A2	Up	0.0279283964
GSE28863_A3	Up	0.2166438492
GSE28863_A4	Down	-0.0477676327
GSE48662	Down	-0.0872634290

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Not regulated by compounds

Drugs

Not regulated by drugs

MicroRNAs

mirTarBase

No target information from mirTarBase

mirRecord

No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

1.General information
2.Neighbors in the network
3.Gene Ontology Annotation
4.Expression levels
5.Regulation
6.Text-mining results