HCSGD entry for NLK
1. General information
| Official gene symbol | NLK |
|---|---|
| Entrez ID | 51701 |
| Gene full name | nemo-like kinase |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000287 | Magnesium ion binding | IEA ISS | molecular_function |
| GO:0004672 | Protein kinase activity | TAS | molecular_function |
| GO:0004707 | MAP kinase activity | IEA ISS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA ISS | molecular_function |
| GO:0005634 | Nucleus | IEA ISS | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA ISS | biological_process |
| GO:0006468 | Protein phosphorylation | ISS | biological_process |
| GO:0007179 | Transforming growth factor beta receptor signaling pathway | IMP | biological_process |
| GO:0008134 | Transcription factor binding | IPI | molecular_function |
| GO:0016055 | Wnt signaling pathway | IEA | biological_process |
| GO:0018107 | Peptidyl-threonine phosphorylation | IEA ISS | biological_process |
| GO:0030178 | Negative regulation of Wnt signaling pathway | IEA ISS | biological_process |
| GO:0031625 | Ubiquitin protein ligase binding | IPI | molecular_function |
| GO:0033136 | Serine phosphorylation of STAT3 protein | IEA ISS | biological_process |
| GO:0035556 | Intracellular signal transduction | ISS | biological_process |
| GO:0042169 | SH2 domain binding | IEA ISS | molecular_function |
| GO:0046777 | Protein autophosphorylation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3971499715 | 0.2098447133 | 0.9999902473 | 0.8850990710 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3227482861 |
| GSE13712_SHEAR | Up | 0.1919507009 |
| GSE13712_STATIC | Down | -0.0076574039 |
| GSE19018 | Down | -0.6669194518 |
| GSE19899_A1 | Down | -0.0580952583 |
| GSE19899_A2 | Up | 0.2790723906 |
| PubMed_21979375_A1 | Down | -0.0604167252 |
| PubMed_21979375_A2 | Up | 0.1928507394 |
| GSE35957 | Down | -0.0572617059 |
| GSE36640 | Down | -0.0206841916 |
| GSE54402 | Up | 0.0239453597 |
| GSE9593 | Down | -0.0136957299 |
| GSE43922 | Down | -0.1367272884 |
| GSE24585 | Up | 0.0878050339 |
| GSE37065 | Up | 0.2549079783 |
| GSE28863_A1 | Up | 0.0086530521 |
| GSE28863_A2 | Down | -0.1361875698 |
| GSE28863_A3 | Down | -1.0991941422 |
| GSE28863_A4 | Up | 0.2452670678 |
| GSE48662 | Up | 0.1568429928 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-181c-5p | MIMAT0000258 | MIRT000233 | Luciferase reporter assay | Functional MTI | 19585654 |
| hsa-miR-181b-5p | MIMAT0000257 | MIRT000238 | Luciferase reporter assay | Functional MTI | 19585654 |
| hsa-miR-181a-5p | MIMAT0000256 | MIRT000243 | Luciferase reporter assay | Functional MTI | 19585654 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024563 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026531 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT035518 | Luciferase reporter assay | Functional MTI | 23416699 |
| hsa-miR-23a-3p | MIMAT0000078 | MIRT050387 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-181b-5p | MIMAT0000257 | 1 | hsa-miR-181b | {Western blot} | {downregulation} | 19585654 | |
| hsa-miR-181a-5p | MIMAT0000256 | 1 | hsa-miR-181a | {Western blot} | {downregulation} | 19585654 | |
| hsa-miR-181c-5p | MIMAT0000258 | 1 | hsa-miR-181c | {Western blot} | {downregulation} | 19585654 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
