HCSGD entry for SUFU

1. General information

Official gene symbolSUFU
Entrez ID51684
Gene full namesuppressor of fused homolog (Drosophila)
Other gene symbolsPRO1280 SUFUH SUFUXL
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0001501Skeletal system developmentTASbiological_process
GO:0001843Neural tube closureIEAbiological_process
GO:0001947Heart loopingIEAbiological_process
GO:0003714Transcription corepressor activityTASmolecular_function
GO:0004871Signal transducer activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDA NAScellular_component
GO:0006355Regulation of transcription, DNA-templatedTASbiological_process
GO:0006508ProteolysisTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007275Multicellular organismal developmentTASbiological_process
GO:0008013Beta-catenin bindingIEAmolecular_function
GO:0008134Transcription factor bindingIDAmolecular_function
GO:0019901Protein kinase bindingIPImolecular_function
GO:0021775Smoothened signaling pathway involved in ventral spinal cord interneuron specificationIEAbiological_process
GO:0021776Smoothened signaling pathway involved in spinal cord motor neuron cell fate specificationIEAbiological_process
GO:0042992Negative regulation of transcription factor import into nucleusTASbiological_process
GO:0042994Cytoplasmic sequestering of transcription factorIEAbiological_process
GO:0043433Negative regulation of sequence-specific DNA binding transcription factor activityTASbiological_process
GO:0043588Skin developmentIEAbiological_process
GO:0045668Negative regulation of osteoblast differentiationTASbiological_process
GO:0045879Negative regulation of smoothened signaling pathwayTASbiological_process
GO:0072372Primary ciliumIEAcellular_component
GO:1901621Negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningIEAbiological_process
GO:2000059Negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.16120322180.97995314010.79512851531.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0124533302
GSE13712_SHEARUp0.3002789753
GSE13712_STATICUp0.1348638334
GSE19018Up0.0062243252
GSE19899_A1Up0.0375685361
GSE19899_A2Up0.2590400453
PubMed_21979375_A1Up0.2328256475
PubMed_21979375_A2Up0.4156714432
GSE35957Up0.1900904868
GSE36640Up0.2744700758
GSE54402Down-0.0077467540
GSE9593Down-0.0303984774
GSE43922Up0.0455285945
GSE24585Up0.0722114187
GSE37065Up0.0196462165
GSE28863_A1Up0.3117548292
GSE28863_A2Up0.2641345523
GSE28863_A3Up0.0595767893
GSE28863_A4Up0.0341830814
GSE48662Up0.1031248996

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-378a-3pMIMAT0000732MIRT000670Reporter assayFunctional MTI18077375
hsa-miR-378a-5pMIMAT0000731MIRT002084Luciferase reporter assay//Western blot//qRT-PCRFunctional MTI18077375
hsa-miR-93-3pMIMAT0004509MIRT038747CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.