HCSGD entry for ENPP1

1. General information

Official gene symbol	ENPP1
Entrez ID	5167
Gene full name	ectonucleotide pyrophosphatase/phosphodiesterase 1
Other gene symbols	ARHR2 M6S1 NPP1 NPPS PC-1 PCA1 PDNP1
Links to Entrez Gene	Links to Entrez Gene

2. Neighbors in the network

This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID	GO term	Evidence	Category
GO:0003676	Nucleic acid binding	IEA	molecular_function
GO:0003824	Catalytic activity	IEA	molecular_function
GO:0004528	Phosphodiesterase I activity	IEA	molecular_function
GO:0004551	Nucleotide diphosphatase activity	IDA TAS	molecular_function
GO:0005044	Scavenger receptor activity	IEA	molecular_function
GO:0005158	Insulin receptor binding	IDA	molecular_function
GO:0005515	Protein binding	IPI	molecular_function
GO:0005524	ATP binding	IDA	molecular_function
GO:0005615	Extracellular space	IDA	cellular_component
GO:0005765	Lysosomal membrane	IDA	cellular_component
GO:0005886	Plasma membrane	IDA TAS	cellular_component
GO:0006091	Generation of precursor metabolites and energy	IDA	biological_process
GO:0006766	Vitamin metabolic process	TAS	biological_process
GO:0006767	Water-soluble vitamin metabolic process	TAS	biological_process
GO:0006771	Riboflavin metabolic process	TAS	biological_process
GO:0006796	Phosphate-containing compound metabolic process	IDA	biological_process
GO:0006955	Immune response	IEA	biological_process
GO:0009143	Nucleoside triphosphate catabolic process	IDA	biological_process
GO:0009986	Cell surface	IDA	cellular_component
GO:0016021	Integral component of membrane	IEA	cellular_component
GO:0016323	Basolateral plasma membrane	NAS	cellular_component
GO:0030247	Polysaccharide binding	IEA	molecular_function
GO:0030279	Negative regulation of ossification	IEA	biological_process
GO:0030308	Negative regulation of cell growth	IDA	biological_process
GO:0030500	Regulation of bone mineralization	IC	biological_process
GO:0030505	Inorganic diphosphate transport	IDA	biological_process
GO:0030643	Cellular phosphate ion homeostasis	IDA	biological_process
GO:0030730	Sequestering of triglyceride	IDA	biological_process
GO:0031214	Biomineral tissue development	IEA	biological_process
GO:0031953	Negative regulation of protein autophosphorylation	IDA	biological_process
GO:0032869	Cellular response to insulin stimulus	IDA	biological_process
GO:0035529	NADH pyrophosphatase activity	IEA	molecular_function
GO:0042803	Protein homodimerization activity	IDA	molecular_function
GO:0044281	Small molecule metabolic process	TAS	biological_process
GO:0045599	Negative regulation of fat cell differentiation	IDA	biological_process
GO:0045719	Negative regulation of glycogen biosynthetic process	IDA	biological_process
GO:0046325	Negative regulation of glucose import	IDA	biological_process
GO:0046627	Negative regulation of insulin receptor signaling pathway	IDA	biological_process
GO:0046849	Bone remodeling	IEA	biological_process
GO:0046872	Metal ion binding	IEA	molecular_function
GO:0047429	Nucleoside-triphosphate diphosphatase activity	IDA	molecular_function
GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process	IDA	biological_process
GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding	IC	molecular_function

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4. Expression levels in datasets

Meta-analysis result

p-value up	p-value down	FDR up	FDR down
0.5119945405	0.0016657536	0.9999902473	0.0784334526

Individual experiment result
( "-" represent NA in the specific microarray platform )

Data source	Up or down	Log fold change
GSE11954	Down	-0.1275862376
GSE13712_SHEAR	Down	-0.1062625836
GSE13712_STATIC	Down	-0.2679315450
GSE19018	Up	0.6249255616
GSE19899_A1	Down	-0.0921587127
GSE19899_A2	Down	-0.2671509210
PubMed_21979375_A1	Down	-2.2405872436
PubMed_21979375_A2	Down	-1.1683975852
GSE35957	Up	0.2850397767
GSE36640	Down	-4.4547914224
GSE54402	Down	-1.1536303050
GSE9593	Down	-0.3176981690
GSE43922	Down	-0.0214623326
GSE24585	Down	-0.3755798265
GSE37065	Up	0.3905861859
GSE28863_A1	Down	-0.4822311408
GSE28863_A2	Up	0.7159645751
GSE28863_A3	Down	-1.1302787487
GSE28863_A4	Down	-0.1431641729
GSE48662	Up	0.2816354732

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Not regulated by compounds

Drugs

Name	Drug	Accession number
Ribavirin	DB00811	APRD00081 \| EXPT02825 \| DB01693
Amifostine	DB01143	APRD00021

MicroRNAs

mirTarBase

No target information from mirTarBase

mirRecord

No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.

PubMed ID of the article	Sentenece the gene occurs
6269614	With ageing the activity of 5-nucleotidase significantly increases whereas that of alkaline phosphodiesterase I decreases

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Navigator

1.General information
2.Neighbors in the network
3.Gene Ontology Annotation
4.Expression levels
5.Regulation
6.Text-mining results

HCSGD entry for ENPP1

1. General information

2. Neighbors in the network

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

4. Expression levels in datasets

Meta-analysis result

Individual experiment result ( "-" represent NA in the specific microarray platform )

( "-" represent NA in the specific microarray platform )

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Drugs

Name

Drug

Accession number