HCSGD entry for PDK3
1. General information
| Official gene symbol | PDK3 |
|---|---|
| Entrez ID | 5165 |
| Gene full name | pyruvate dehydrogenase kinase, isozyme 3 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004672 | Protein kinase activity | IDA | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0004740 | Pyruvate dehydrogenase (acetyl-transferring) kinase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IDA | molecular_function |
| GO:0005739 | Mitochondrion | TAS | cellular_component |
| GO:0005759 | Mitochondrial matrix | TAS | cellular_component |
| GO:0006006 | Glucose metabolic process | IEA | biological_process |
| GO:0006090 | Pyruvate metabolic process | TAS | biological_process |
| GO:0010510 | Regulation of acetyl-CoA biosynthetic process from pyruvate | IMP TAS | biological_process |
| GO:0010906 | Regulation of glucose metabolic process | IMP | biological_process |
| GO:0018105 | Peptidyl-serine phosphorylation | IDA | biological_process |
| GO:0035357 | Peroxisome proliferator activated receptor signaling pathway | IMP | biological_process |
| GO:0044237 | Cellular metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0071333 | Cellular response to glucose stimulus | ISS | biological_process |
| GO:0071398 | Cellular response to fatty acid | IMP | biological_process |
| GO:0097411 | Hypoxia-inducible factor-1alpha signaling pathway | IMP | biological_process |
| GO:2000377 | Regulation of reactive oxygen species metabolic process | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1634734623 | 0.0673199271 | 0.8008161176 | 0.4897533997 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4662481552 |
| GSE13712_SHEAR | Down | -0.7297011679 |
| GSE13712_STATIC | Down | -0.2943630264 |
| GSE19018 | Up | 0.4290587753 |
| GSE19899_A1 | Up | 0.0261018771 |
| GSE19899_A2 | Up | 0.0088142569 |
| PubMed_21979375_A1 | Up | 0.5284168611 |
| PubMed_21979375_A2 | Up | 0.0826750955 |
| GSE35957 | Down | -0.2089664279 |
| GSE36640 | Down | -1.0702581603 |
| GSE54402 | Up | 1.2827022603 |
| GSE9593 | Down | -0.2357031538 |
| GSE43922 | Up | 0.0519280259 |
| GSE24585 | Down | -0.4551670360 |
| GSE37065 | Up | 0.3786053873 |
| GSE28863_A1 | Up | 0.0401744395 |
| GSE28863_A2 | Up | 0.9132819701 |
| GSE28863_A3 | Up | 0.0684637875 |
| GSE28863_A4 | Down | -0.6433885553 |
| GSE48662 | Down | -0.0921182587 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 15610763 | Pyruvate dehydrogenase kinase 3 (Pdk3) and connective tissue growth factor (Ctgf) were up-regulated and hyaluronan synthase 3 (Has3) down-regulated under both conditions |
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