HCSGD entry for PDK2

1. General information

Official gene symbolPDK2
Entrez ID5164
Gene full namepyruvate dehydrogenase kinase, isozyme 2
Other gene symbolsPDHK2 PDKII
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004672Protein kinase activityTASmolecular_function
GO:0004674Protein serine/threonine kinase activityIEAmolecular_function
GO:0004740Pyruvate dehydrogenase (acetyl-transferring) kinase activityIDA IEAmolecular_function
GO:0005524ATP bindingIDA IEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005739MitochondrionIDAcellular_component
GO:0005759Mitochondrial matrixTAScellular_component
GO:0005967Mitochondrial pyruvate dehydrogenase complexIEA ISScellular_component
GO:0006006Glucose metabolic processIEAbiological_process
GO:0006090Pyruvate metabolic processTASbiological_process
GO:0006111Regulation of gluconeogenesisIEA ISSbiological_process
GO:0006468Protein phosphorylationIDA TASbiological_process
GO:0006885Regulation of pHIEA ISSbiological_process
GO:0008286Insulin receptor signaling pathwayIEA ISSbiological_process
GO:0010510Regulation of acetyl-CoA biosynthetic process from pyruvateIEA ISS TASbiological_process
GO:0010565Regulation of cellular ketone metabolic processISSbiological_process
GO:0010906Regulation of glucose metabolic processISSbiological_process
GO:0031670Cellular response to nutrientIEA ISSbiological_process
GO:0034614Cellular response to reactive oxygen speciesIMPbiological_process
GO:0042593Glucose homeostasisIEA ISSbiological_process
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0044237Cellular metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0072332Intrinsic apoptotic signaling pathway by p53 class mediatorIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.12724750200.45840673230.72652527111.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0882902737
GSE13712_SHEARDown-0.3530548172
GSE13712_STATICUp0.0316615098
GSE19018Up0.1060536315
GSE19899_A1Down-0.0893703760
GSE19899_A2Up0.5368120947
PubMed_21979375_A1Down-0.3774572760
PubMed_21979375_A2Up0.2082340569
GSE35957Up0.3859678129
GSE36640Up0.4681200286
GSE54402Down-0.2668787846
GSE9593Up0.5795718804
GSE43922Down-0.7619848092
GSE24585Up0.6673595314
GSE37065Down-0.1715103887
GSE28863_A1Up0.1309233800
GSE28863_A2Down-0.0002141161
GSE28863_A3Down-0.0540331663
GSE28863_A4Down-0.1732094650
GSE48662Up0.4654222331

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

4-({(2R,5S)-2,5-DIMETHYL-4-[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]PIPERAZIN-1-YL}CARBONYL)BENZONITRILEDB08608 -
(N-{4-[(ETHYLANILINO)SULFONYL]-2-METHYLPHENYL}-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANAMIDEDB08609 -
N-(2-AMINOETHYL)-2-{3-CHLORO-4-[(4-ISOPROPYLBENZYL)OXY]PHENYL} ACETAMIDEDB08610 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-25-3pMIMAT0000081MIRT050290CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.