HCSGD entry for PDK1
1. General information
| Official gene symbol | PDK1 |
|---|---|
| Entrez ID | 5163 |
| Gene full name | pyruvate dehydrogenase kinase, isozyme 1 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004672 | Protein kinase activity | IDA | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0004740 | Pyruvate dehydrogenase (acetyl-transferring) kinase activity | IDA IMP | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005739 | Mitochondrion | TAS | cellular_component |
| GO:0005759 | Mitochondrial matrix | TAS | cellular_component |
| GO:0005967 | Mitochondrial pyruvate dehydrogenase complex | IEA | cellular_component |
| GO:0006006 | Glucose metabolic process | IEA | biological_process |
| GO:0006090 | Pyruvate metabolic process | TAS | biological_process |
| GO:0006468 | Protein phosphorylation | IDA IMP | biological_process |
| GO:0008283 | Cell proliferation | IMP | biological_process |
| GO:0008631 | Intrinsic apoptotic signaling pathway in response to oxidative stress | IMP | biological_process |
| GO:0010510 | Regulation of acetyl-CoA biosynthetic process from pyruvate | IEA TAS | biological_process |
| GO:0010906 | Regulation of glucose metabolic process | IMP | biological_process |
| GO:0016301 | Kinase activity | IEA | molecular_function |
| GO:0044237 | Cellular metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0097411 | Hypoxia-inducible factor-1alpha signaling pathway | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3310014133 | 0.0011142244 | 0.9999902473 | 0.0634088553 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.8000977739 |
| GSE13712_SHEAR | Up | 0.0079203549 |
| GSE13712_STATIC | Up | 0.0717341498 |
| GSE19018 | Up | 1.4556765292 |
| GSE19899_A1 | Down | -0.5699413641 |
| GSE19899_A2 | Down | -1.7134674021 |
| PubMed_21979375_A1 | Down | -1.3627347378 |
| PubMed_21979375_A2 | Down | -1.4069457506 |
| GSE35957 | Down | -0.6842393689 |
| GSE36640 | Down | -1.3849025087 |
| GSE54402 | Down | -0.3159062080 |
| GSE9593 | Down | -0.1024689150 |
| GSE43922 | Down | -1.8287998571 |
| GSE24585 | Down | -0.2586312925 |
| GSE37065 | Up | 0.0996722227 |
| GSE28863_A1 | Up | 0.6885115476 |
| GSE28863_A2 | Up | 1.1685552782 |
| GSE28863_A3 | Down | -0.7870109657 |
| GSE28863_A4 | Down | -0.8062810188 |
| GSE48662 | Down | -0.0337633146 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| 4-[(3-CHLORO-4-{[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]AMINO}PHENYL)SULFONYL]-N,N-DIMETHYLBENZAMIDE | DB07403 | - |
| Dichloroacetic Acid | DB08809 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-375 | MIMAT0000728 | MIRT000055 | Immunohistochemistry//Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 21533613 |
| hsa-miR-375 | MIMAT0000728 | MIRT000055 | Western blot | Functional MTI | 20215506 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT020770 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029318 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032356 | Proteomics | Functional MTI (Weak) | 18668040 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23685455 | BRAF(V600E)-induced senescence was accompanied by simultaneous suppression of the PDH-inhibitory enzyme pyruvate dehydrogenase kinase 1 (PDK1) and induction of the PDH-activating enzyme pyruvate dehydrogenase phosphatase 2 (PDP2) |
| 23685455 | Further supporting a crucial role of PDH in OIS, enforced normalization of either PDK1 or PDP2 expression levels inhibited PDH and abrogated OIS, thereby licensing BRAF(V600E)-driven melanoma development |
| 23685455 | Finally, depletion of PDK1 eradicated melanoma subpopulations resistant to targeted BRAF inhibition, and caused regression of established melanomas |
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