HCSGD entry for PDHB

1. General information

Official gene symbolPDHB
Entrez ID5162
Gene full namepyruvate dehydrogenase (lipoamide) beta
Other gene symbolsPDHBD PDHE1-B PHE1B
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003824Catalytic activityIEAmolecular_function
GO:0004738Pyruvate dehydrogenase activityIDAmolecular_function
GO:0004739Pyruvate dehydrogenase (acetyl-transferring) activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005759Mitochondrial matrixTAScellular_component
GO:0006006Glucose metabolic processIEAbiological_process
GO:0006086Acetyl-CoA biosynthetic process from pyruvateIDAbiological_process
GO:0006090Pyruvate metabolic processTASbiological_process
GO:0006099Tricarboxylic acid cycleIDAbiological_process
GO:0010510Regulation of acetyl-CoA biosynthetic process from pyruvateTASbiological_process
GO:0044237Cellular metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045254Pyruvate dehydrogenase complexIDAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.95186798750.08383520760.99999024730.5500066052

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.5650286047
GSE13712_SHEARDown-0.0753824735
GSE13712_STATICDown-0.0914631752
GSE19018Up0.3121559279
GSE19899_A1Down-0.4055282141
GSE19899_A2Down-0.0701713238
PubMed_21979375_A1Down-0.2122558689
PubMed_21979375_A2Down-0.7157575109
GSE35957Up0.1293669860
GSE36640Down-0.0862627705
GSE54402Up0.0214657410
GSE9593Down-0.2173385271
GSE43922Down-0.3916148549
GSE24585Up0.0809543383
GSE37065Down-0.1247240689
GSE28863_A1Up0.1469046724
GSE28863_A2Up0.0242587048
GSE28863_A3Up0.0840783323
GSE28863_A4Down-0.1213460552
GSE48662Down-0.2059009422

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

NADHDB00157 NUTR00041 | DB01907 | EXPT02287 | DB03527

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-98-5pMIMAT0000096MIRT027487MicroarrayFunctional MTI (Weak)19088304
hsa-miR-1260bMIMAT0015041MIRT052771CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.