HCSGD entry for PIAS4
1. General information
| Official gene symbol | PIAS4 |
|---|---|
| Entrez ID | 51588 |
| Gene full name | protein inhibitor of activated STAT, 4 |
| Other gene symbols | PIASY Piasg ZMIZ6 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA NAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0008270 | Zinc ion binding | NAS | molecular_function |
| GO:0016055 | Wnt signaling pathway | IEA | biological_process |
| GO:0016363 | Nuclear matrix | IEA | cellular_component |
| GO:0016605 | PML body | IEA | cellular_component |
| GO:0016925 | Protein sumoylation | IEA IMP | biological_process |
| GO:0019789 | SUMO ligase activity | IDA IMP | molecular_function |
| GO:0031625 | Ubiquitin protein ligase binding | IPI | molecular_function |
| GO:0032088 | Negative regulation of NF-kappaB transcription factor activity | IEA | biological_process |
| GO:0033235 | Positive regulation of protein sumoylation | IDA | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IDA NAS | biological_process |
| GO:1902174 | Positive regulation of keratinocyte apoptotic process | ISS | biological_process |
| GO:1902231 | Positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0534321948 | 0.9352633601 | 0.5053483513 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0867875749 |
| GSE13712_SHEAR | Up | 0.0144224009 |
| GSE13712_STATIC | Down | -0.0281053443 |
| GSE19018 | Up | 0.1830722225 |
| GSE19899_A1 | Up | 0.3620777628 |
| GSE19899_A2 | Up | 1.3964051451 |
| PubMed_21979375_A1 | Up | 0.4169916965 |
| PubMed_21979375_A2 | Up | 0.6949713105 |
| GSE35957 | Down | -0.5339573689 |
| GSE36640 | Down | -0.0376898142 |
| GSE54402 | Up | 0.2209072173 |
| GSE9593 | Down | -0.3201975544 |
| GSE43922 | Up | 0.3571362408 |
| GSE24585 | Up | 0.2185602523 |
| GSE37065 | Up | 0.0491912794 |
| GSE28863_A1 | Down | -0.1200417686 |
| GSE28863_A2 | Down | -0.2777136434 |
| GSE28863_A3 | Up | 0.3619720986 |
| GSE28863_A4 | Up | 0.1272380462 |
| GSE48662 | Up | 0.1443165760 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-324-5p | MIMAT0000761 | MIRT043227 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 6 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25701873 | This satellite cell senescence is due to accumulation of the SUMO ligase PIASy, a substrate of TRIM32 |
| 23893515 | Here, we determined the genome-wide localization of SUMO1 and SUMO2/3, as well as of UBC9 (encoded by UBE2I) and PIASY (encoded by PIAS4), two markers for active sumoylation, along with Pol II and histone marks in proliferating versus senescent human fibroblasts together with gene expression profiling |
| 22505452 | Furthermore, TRIM32-deficient primary myoblasts underwent premature senescence and impaired myogenesis due to accumulation of PIAS4, an E3 SUMO ligase and TRIM32 substrate that was previously shown to be associated with senescence |
| 22505452 | Trim32-/- muscles had substantially fewer activated satellite cells, increased PIAS4 levels, and growth failure compared with wild-type muscles |
| 19436740 | Moreover, we provide evidence that PIASy functions as a specific SUMO E3-ligase for DRIL1 and promotes its sumoylation both in vitro and in vivo |
| 19436740 | Furthermore, consistent with the subnuclear localization of PIASy in the Matrix-Associated Region (MAR), SUMO-modified DRIL1 species are found exclusively in the MAR fraction |
| 17374992 | We have shown recently that the E3 SUMO ligase PIASy actively contributes to execution of the senescence program, thus, providing the first evidence for a direct role of SUMO modification in this process |
| 16793547 | The E3 SUMO ligase PIASy is a regulator of cellular senescence and apoptosis |
| 16793547 | Here we show that overexpression of the E3 SUMO ligase PIASy in normal human fibroblasts recruits the p53 and Rb tumor suppressor pathways to provoke a senescence arrest |
| 16793547 | By contrast, in Rb-deficient fibroblasts, expression of PIASy leads to p53-dependent apoptosis |
| 16793547 | Induction of senescence requires PIASy E3 activity and is specific for this member of the PIAS ligase family |
| 16793547 | PIASy stimulates sumoylation and transcriptional activity of p53 and increases Rb-dependent corepression through recruitment to E2F-responsive promoters |
| 16793547 | Viral oncoprotein E6 suppresses both PIASy-induced senescence and sumoylation of PIASy substrates |
| 16793547 | Finally, we show that fibroblasts lacking PIASy exhibit a highly reduced propensity to undergo senescence in response to a prosenescence stimulus |
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