HCSGD entry for PDGFRA

1. General information

Official gene symbol	PDGFRA
Entrez ID	5156
Gene full name	platelet-derived growth factor receptor, alpha polypeptide
Other gene symbols	CD140A PDGFR-2 PDGFR2 RHEPDGFRA
Links to Entrez Gene	Links to Entrez Gene

2. Neighbors in the network

This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID	GO term	Evidence	Category
GO:0001553	Luteinization	IEA ISS	biological_process
GO:0001701	In utero embryonic development	IEA	biological_process
GO:0001775	Cell activation	TAS	biological_process
GO:0004714	Transmembrane receptor protein tyrosine kinase activity	IDA	molecular_function
GO:0005018	Platelet-derived growth factor alpha-receptor activity	IDA IEA IMP	molecular_function
GO:0005021	Vascular endothelial growth factor-activated receptor activity	IDA	molecular_function
GO:0005161	Platelet-derived growth factor receptor binding	IPI	molecular_function
GO:0005515	Protein binding	IPI	molecular_function
GO:0005524	ATP binding	IEA	molecular_function
GO:0005634	Nucleus	ISS	cellular_component
GO:0005737	Cytoplasm	ISS	cellular_component
GO:0005886	Plasma membrane	TAS	cellular_component
GO:0005887	Integral component of plasma membrane	IDA	cellular_component
GO:0007173	Epidermal growth factor receptor signaling pathway	TAS	biological_process
GO:0007204	Positive regulation of cytosolic calcium ion concentration	IMP	biological_process
GO:0008210	Estrogen metabolic process	IEA	biological_process
GO:0008284	Positive regulation of cell proliferation	IMP	biological_process
GO:0008543	Fibroblast growth factor receptor signaling pathway	TAS	biological_process
GO:0009897	External side of plasma membrane	IEA	cellular_component
GO:0010544	Negative regulation of platelet activation	IDA	biological_process
GO:0010863	Positive regulation of phospholipase C activity	IMP	biological_process
GO:0014068	Positive regulation of phosphatidylinositol 3-kinase signaling	TAS	biological_process
GO:0016032	Viral process	IEA	biological_process
GO:0018108	Peptidyl-tyrosine phosphorylation	IDA	biological_process
GO:0023019	Signal transduction involved in regulation of gene expression	IEA	biological_process
GO:0030198	Extracellular matrix organization	IEA	biological_process
GO:0030324	Lung development	IEA	biological_process
GO:0030325	Adrenal gland development	IEA	biological_process
GO:0030335	Positive regulation of cell migration	IDA IMP	biological_process
GO:0030539	Male genitalia development	IEA	biological_process
GO:0031226	Intrinsic component of plasma membrane	IDA	cellular_component
GO:0033327	Leydig cell differentiation	IEA	biological_process
GO:0035790	Platelet-derived growth factor receptor-alpha signaling pathway	IMP	biological_process
GO:0036120	Cellular response to platelet-derived growth factor stimulus	IDA IMP	biological_process
GO:0038085	Vascular endothelial growth factor binding	IPI	molecular_function
GO:0038091	Positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	IDA	biological_process
GO:0038095	Fc-epsilon receptor signaling pathway	TAS	biological_process
GO:0042060	Wound healing	IEA ISS	biological_process
GO:0042475	Odontogenesis of dentin-containing tooth	IEA	biological_process
GO:0042803	Protein homodimerization activity	IDA	molecular_function
GO:0043552	Positive regulation of phosphatidylinositol 3-kinase activity	IMP	biological_process
GO:0045087	Innate immune response	TAS	biological_process
GO:0045740	Positive regulation of DNA replication	IDA	biological_process
GO:0046777	Protein autophosphorylation	IDA	biological_process
GO:0048008	Platelet-derived growth factor receptor signaling pathway	IDA	biological_process
GO:0048011	Neurotrophin TRK receptor signaling pathway	TAS	biological_process
GO:0048015	Phosphatidylinositol-mediated signaling	IMP TAS	biological_process
GO:0048146	Positive regulation of fibroblast proliferation	IDA	biological_process
GO:0048407	Platelet-derived growth factor binding	IDA IEA IPI	molecular_function
GO:0048557	Embryonic digestive tract morphogenesis	IEA ISS	biological_process
GO:0048701	Embryonic cranial skeleton morphogenesis	IEA ISS	biological_process
GO:0048704	Embryonic skeletal system morphogenesis	ISS	biological_process
GO:0050920	Regulation of chemotaxis	IMP	biological_process
GO:0055003	Cardiac myofibril assembly	IEA ISS	biological_process
GO:0060021	Palate development	IEA	biological_process
GO:0060325	Face morphogenesis	IEA	biological_process
GO:0060326	Cell chemotaxis	IEA IMP	biological_process
GO:0061298	Retina vasculature development in camera-type eye	IEA ISS	biological_process
GO:0070374	Positive regulation of ERK1 and ERK2 cascade	IMP	biological_process
GO:0070527	Platelet aggregation	IMP	biological_process
GO:0071230	Cellular response to amino acid stimulus	IEA	biological_process
GO:0072277	Metanephric glomerular capillary formation	IEA ISS	biological_process
GO:2000249	Regulation of actin cytoskeleton reorganization	TAS	biological_process
GO:2000739	Regulation of mesenchymal stem cell differentiation	IMP	biological_process

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4. Expression levels in datasets

Meta-analysis result

p-value up	p-value down	FDR up	FDR down
0.3795335778	0.4838737662	0.9999902473	1.0000000000

Individual experiment result
( "-" represent NA in the specific microarray platform )

Data source	Up or down	Log fold change
GSE11954	Up	0.0260661216
GSE13712_SHEAR	Down	-0.0417569015
GSE13712_STATIC	Up	0.0594383236
GSE19018	Down	-0.7853011181
GSE19899_A1	Down	-0.0703066191
GSE19899_A2	Down	-0.1736673221
PubMed_21979375_A1	Up	0.1042112724
PubMed_21979375_A2	Up	0.0815517711
GSE35957	Down	-0.1281087834
GSE36640	Up	0.5631576946
GSE54402	Up	0.0544927760
GSE9593	Up	0.0549651344
GSE43922	-	-
GSE24585	-	-
GSE37065	-	-
GSE28863_A1	Up	0.6403812568
GSE28863_A2	Up	0.5049171408
GSE28863_A3	Up	0.0372398723
GSE28863_A4	Down	-0.1449983443
GSE48662	Down	-0.4635828924

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Not regulated by compounds

Drugs

Name	Drug	Accession number
Becaplermin	DB00102	BTD00053 \| BIOD00053
Imatinib	DB00619	APRD01028 \| EXPT02967 \| DB03261
Sunitinib	DB01268	DB07417
XL820	DB05146	-
MP470	DB05216	-
Olaratumab	DB06043	-
Pazopanib	DB06589	-
Regorafenib	DB08896	-
Ponatinib	DB08901	-

MicroRNAs

mirTarBase

MiRNA_name	mirBase ID	miRTarBase ID	Experiment	Support type	References (Pubmed ID)
hsa-let-7b-5p	MIMAT0000063	MIRT004955	qRT-PCR	Functional MTI (Weak)	17942906
hsa-miR-140-5p	MIMAT0000431	MIRT006218	Luciferase reporter assay//Western blot	Functional MTI	22012839
hsa-miR-34a-5p	MIMAT0000255	MIRT006212	Immunoblot//Luciferase reporter assay//Microarray//qRT-PCR	Functional MTI	22479456
hsa-miR-26b-5p	MIMAT0000083	MIRT030342	Microarray	Functional MTI (Weak)	19088304

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mirRecord

No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

1.General information
2.Neighbors in the network
3.Gene Ontology Annotation
4.Expression levels
5.Regulation
6.Text-mining results

HCSGD entry for PDGFRA

1. General information

2. Neighbors in the network

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

4. Expression levels in datasets

Meta-analysis result

Individual experiment result ( "-" represent NA in the specific microarray platform )

( "-" represent NA in the specific microarray platform )

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Drugs

Name

Drug

Accession number

MicroRNAs

mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

Individual experiment result
( "-" represent NA in the specific microarray platform )