HCSGD entry for NELFCD
1. General information
| Official gene symbol | NELFCD |
|---|---|
| Entrez ID | 51497 |
| Gene full name | negative elongation factor complex member C/D |
| Other gene symbols | NELF-C NELF-D TH1 TH1L |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006368 | Transcription elongation from RNA polymerase II promoter | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016032 | Viral process | TAS | biological_process |
| GO:0032021 | NELF complex | IDA | cellular_component |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0050434 | Positive regulation of viral transcription | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9059483492 | 0.0595153338 | 0.9999902473 | 0.4595198299 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0245580173 |
| GSE13712_SHEAR | Down | -0.2054136761 |
| GSE13712_STATIC | Down | -0.0578984044 |
| GSE19018 | Down | -0.2241767061 |
| GSE19899_A1 | Down | -0.3068140595 |
| GSE19899_A2 | Up | 0.3645397072 |
| PubMed_21979375_A1 | Up | 0.4571476765 |
| PubMed_21979375_A2 | Up | 0.5795892871 |
| GSE35957 | Down | -0.6360759835 |
| GSE36640 | Down | -1.2787801439 |
| GSE54402 | Up | 0.3758023089 |
| GSE9593 | Down | -0.2463386293 |
| GSE43922 | Down | -0.0373174011 |
| GSE24585 | Down | -0.3103415664 |
| GSE37065 | Down | -0.2885893791 |
| GSE28863_A1 | Down | -0.0402043900 |
| GSE28863_A2 | Down | -0.3184221950 |
| GSE28863_A3 | Down | -0.3171922260 |
| GSE28863_A4 | Up | 0.0318968343 |
| GSE48662 | Down | -0.2088929014 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT002804 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-1 | MIMAT0000416 | MIRT002804 | pSILAC//Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1 | MIMAT0000416 | MIRT002804 | Proteomics;Microarray | Non-Functional MTI (Weak) | 18668037 |
| hsa-miR-375 | MIMAT0000728 | MIRT020019 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025484 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027792 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030245 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT037145 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | NA | hsa-miR-1 | 15685193 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24925089 | JMJD3 also interacts with T-bet factor and induces Th1 differentiation of CD4(+) T cells |
| 22080947 | In accordance with these observations, ras-specific Th1 lymphocytes could be detected in mice, in which oncogene-induced senescence had been triggered by hepatic expression of Nras(G12V) |
| 19458122 | The inflammatory response was found to be significantly decreased in bortezomib-treated mice as reflected by a decreased infiltration of CD4(+) T cells and a significantly decreased Th1 cytokine expression in the kidneys |
| 16821141 | In inflamed portal tracts of PBC, CD4+ T cells of Th1 type expressing IFN-gamma or CXCR3 are aggregated and more commonly detected around injured bile ducts than Th2-type CD4+ T cells expressing IL-4 or CCR4, indicating that Th1-dominant cellular immunity plays a more-prominent role in recruitment of memory T-cell subsets in PBC and may be responsible for the progressive bile duct damage |
| 11830522 | Germ-line p53-targeted disruption inhibits helicobacter-induced premalignant lesions and invasive gastric carcinoma through down-regulation of Th1 proinflammatory responses |
| 11830522 | In sera from WT mice, IgG2a, considered a proinflammatory Th1 response, continued to rise throughout the 15-month study (P < 0 |
| 11830522 | Our results support the hypothesis that germ-line deletion of one p53 allele results in a down-regulated Th1 response to gastric helicobacter infection, possibly because of T-cell senescence, which may indirectly protect against the development of gastric cancer and other epithelial-derived neoplasms associated with chronic inflammation |
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