HCSGD entry for LIMA1
1. General information
| Official gene symbol | LIMA1 |
|---|---|
| Entrez ID | 51474 |
| Gene full name | LIM domain and actin binding 1 |
| Other gene symbols | EPLIN SREBP3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001725 | Stress fiber | IDA | cellular_component |
| GO:0003785 | Actin monomer binding | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0005925 | Focal adhesion | IDA | cellular_component |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0015629 | Actin cytoskeleton | IDA IEA | cellular_component |
| GO:0030835 | Negative regulation of actin filament depolymerization | IDA | biological_process |
| GO:0031529 | Ruffle organization | IDA | biological_process |
| GO:0051015 | Actin filament binding | IDA | molecular_function |
| GO:0051017 | Actin filament bundle assembly | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9698521067 | 0.0352798906 | 0.9999902473 | 0.3557862069 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4771865234 |
| GSE13712_SHEAR | Down | -0.2186384250 |
| GSE13712_STATIC | Down | -0.0107005513 |
| GSE19018 | Down | -0.0234391456 |
| GSE19899_A1 | Down | -0.4061569257 |
| GSE19899_A2 | Down | -0.3709883036 |
| PubMed_21979375_A1 | Down | -0.2431996351 |
| PubMed_21979375_A2 | Down | -0.2059547461 |
| GSE35957 | Down | -0.1776587857 |
| GSE36640 | Up | 0.3126476839 |
| GSE54402 | Down | -1.5723802163 |
| GSE9593 | Up | 0.4880796484 |
| GSE43922 | Down | -0.1208796504 |
| GSE24585 | Down | -0.1758705649 |
| GSE37065 | Down | -0.0320095475 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.2123413655 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-130b-3p | MIMAT0000691 | MIRT020165 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT027946 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-33a-5p | MIMAT0000091 | MIRT028234 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-27a-3p | MIMAT0000084 | MIRT028688 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT037112 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-339-5p | MIMAT0000764 | MIRT042791 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-365a-3p | MIMAT0000710 | MIRT044040 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT044924 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047524 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047864 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051156 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26206181 | We also performed functional studies by silencing nine of these genes in young cells, which demonstrated that RNA interference-mediated knockdown of LEPRE1, LIMA1/EPLIN, MAGOHA and MAGOHB induces a premature senescent phenotype in IMR90 cells |
| 26206181 | In conclusion, these results for the first time highlight a possible role of LEPRE1, LIMA1/EPLIN, MAGOHA and MAGOHB in the biology of cellular senescence/aging, thus contributing to gain a deeper knowledge of the molecular mechanisms involved in the senescence program |
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