HCSGD entry for PDE4A
1. General information
| Official gene symbol | PDE4A |
|---|---|
| Entrez ID | 5141 |
| Gene full name | phosphodiesterase 4A, cAMP-specific |
| Other gene symbols | DPDE2 PDE4 PDE46 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004114 | 3',5'-cyclic-nucleotide phosphodiesterase activity | IEA | molecular_function |
| GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity | IDA IGI | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006198 | CAMP catabolic process | IDA IEA IGI IMP | biological_process |
| GO:0007165 | Signal transduction | IEA | biological_process |
| GO:0007608 | Sensory perception of smell | IEA | biological_process |
| GO:0010738 | Regulation of protein kinase A signaling | IEA | biological_process |
| GO:0016020 | Membrane | TAS | cellular_component |
| GO:0030552 | CAMP binding | IGI | molecular_function |
| GO:0032587 | Ruffle membrane | IEA | cellular_component |
| GO:0035690 | Cellular response to drug | IEA | biological_process |
| GO:0043949 | Regulation of cAMP-mediated signaling | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3337134151 | 0.9277203830 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1082026266 |
| GSE13712_SHEAR | Down | -0.1433023906 |
| GSE13712_STATIC | Down | -0.0409502072 |
| GSE19018 | Up | 0.2576959362 |
| GSE19899_A1 | Down | -0.0353598883 |
| GSE19899_A2 | Up | 0.3827692798 |
| PubMed_21979375_A1 | Up | 0.2216608826 |
| PubMed_21979375_A2 | Up | 0.1435545301 |
| GSE35957 | Down | -0.0488368631 |
| GSE36640 | Up | 0.0124851392 |
| GSE54402 | Up | 0.0508901759 |
| GSE9593 | Up | 0.0352934594 |
| GSE43922 | Up | 0.0555000524 |
| GSE24585 | Up | 0.3906121277 |
| GSE37065 | Down | -0.0544380899 |
| GSE28863_A1 | Up | 0.1537802475 |
| GSE28863_A2 | Down | -0.0194603104 |
| GSE28863_A3 | Up | 0.2433248850 |
| GSE28863_A4 | Down | -0.0153430062 |
| GSE48662 | Up | 0.1092860760 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Theophylline | DB00277 | APRD00082 | DB09359 |
| Pentoxifylline | DB00806 | APRD00121 |
| Enprofylline | DB00824 | APRD00273 |
| Ketotifen | DB00920 | APRD01061 |
| Dipyridamole | DB00975 | APRD00360 |
| Iloprost | DB01088 | APRD01027 |
| Oxtriphylline | DB01303 | - |
| Roflumilast | DB01656 | EXPT02802 |
| Piclamilast | DB01791 | EXPT02600 |
| AN2728 | DB05219 | - |
| Apremilast | DB05676 | - |
| PDE4 | DB05876 | - |
| Drotaverine | DB06751 | - |
| (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one | DB06842 | - |
| 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid | DB08299 | - |
| Tofisopam | DB08811 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT016809 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037515 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040823 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
