HCSGD entry for PDE3A

1. General information

Official gene symbolPDE3A
Entrez ID5139
Gene full namephosphodiesterase 3A, cGMP-inhibited
Other gene symbolsCGI-PDE CGI-PDE A CGI-PDE-A
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001556Oocyte maturationIEAbiological_process
GO:00041153',5'-cyclic-AMP phosphodiesterase activityIEAmolecular_function
GO:0004119CGMP-inhibited cyclic-nucleotide phosphodiesterase activityIEAmolecular_function
GO:0005829CytosolTAScellular_component
GO:0006198CAMP catabolic processIDA IMPbiological_process
GO:0006629Lipid metabolic processTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0016101Diterpenoid metabolic processIEAbiological_process
GO:0019933CAMP-mediated signalingIMPbiological_process
GO:0019934CGMP-mediated signalingIMPbiological_process
GO:0030552CAMP bindingIEAmolecular_function
GO:0040020Regulation of meiosisIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0043116Negative regulation of vascular permeabilityIMPbiological_process
GO:0043117Positive regulation of vascular permeabilityIMPbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0051591Response to cAMPIEAbiological_process
GO:0060282Positive regulation of oocyte developmentIEAbiological_process
GO:0071321Cellular response to cGMPIDAbiological_process
GO:0071560Cellular response to transforming growth factor beta stimulusIEPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.11607272140.18868206380.69959929010.8418790847

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0365358018
GSE13712_SHEARDown-0.5101951423
GSE13712_STATICUp0.0279604870
GSE19018Down-0.8187910322
GSE19899_A1Down-0.0146503636
GSE19899_A2Down-0.0313549261
PubMed_21979375_A1Up0.0345186162
PubMed_21979375_A2Down-0.0545275709
GSE35957Up0.6614740401
GSE36640Down-0.2292778159
GSE54402Down-0.5477065005
GSE9593Up0.0793231751
GSE43922Up0.0145090651
GSE24585Up0.1485129920
GSE37065Up0.4479379321
GSE28863_A1Down-0.2515168163
GSE28863_A2Up0.8623350458
GSE28863_A3Up1.3653251946
GSE28863_A4Up0.0217823407
GSE48662Down-0.0243929261

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

MilrinoneDB00235 APRD00010
AnagrelideDB00261 APRD00798
TheophyllineDB00277 APRD00082 | DB09359
LevosimendanDB00922 APRD01296
AminophyllineDB01223 APRD00329
OxtriphyllineDB01303 -
AmrinoneDB01427 -
EnoximoneDB04880 -
TofisopamDB08811 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT001528pSILAC//Proteomics;OtherFunctional MTI (Weak)18668040
hsa-miR-128-3pMIMAT0000424MIRT022078MicroarrayFunctional MTI (Weak)17612493
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.