HCSGD entry for EIF3L
1. General information
| Official gene symbol | EIF3L |
|---|---|
| Entrez ID | 51386 |
| Gene full name | eukaryotic translation initiation factor 3, subunit L |
| Other gene symbols | EIF3EIP EIF3S11 EIF3S6IP HSPC021 HSPC025 MSTP005 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001650 | Fibrillar center | IEA | cellular_component |
| GO:0001731 | Formation of translation preinitiation complex | IEA | biological_process |
| GO:0003743 | Translation initiation factor activity | IC IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005654 | Nucleoplasm | IEA | cellular_component |
| GO:0005852 | Eukaryotic translation initiation factor 3 complex | IDA IEA | cellular_component |
| GO:0006413 | Translational initiation | IC IDA | biological_process |
| GO:0006446 | Regulation of translational initiation | IEA | biological_process |
| GO:0016282 | Eukaryotic 43S preinitiation complex | IEA | cellular_component |
| GO:0033290 | Eukaryotic 48S preinitiation complex | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8386676000 | 0.2726290718 | 0.9999902473 | 0.9987342329 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0218215209 |
| GSE13712_SHEAR | Down | -0.5158187071 |
| GSE13712_STATIC | Down | -0.4682867994 |
| GSE19018 | Up | 0.2612184623 |
| GSE19899_A1 | Up | 0.1136370081 |
| GSE19899_A2 | Up | 0.1162768606 |
| PubMed_21979375_A1 | Up | 0.1982897470 |
| PubMed_21979375_A2 | Up | 0.0452835907 |
| GSE35957 | Down | -0.0728471976 |
| GSE36640 | Down | -0.3207995193 |
| GSE54402 | Up | 0.0676932631 |
| GSE9593 | Up | 0.0201466220 |
| GSE43922 | Down | -0.0255520546 |
| GSE24585 | Up | 0.0946747653 |
| GSE37065 | Down | -0.3821865539 |
| GSE28863_A1 | Up | 0.0735731553 |
| GSE28863_A2 | Down | -0.3387032887 |
| GSE28863_A3 | Up | 0.1494676757 |
| GSE28863_A4 | Up | 0.0974485702 |
| GSE48662 | Down | -0.1635479897 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT023148 | Proteomics | Functional MTI (Weak) | 18668037 |
| hsa-miR-769-3p | MIMAT0003887 | MIRT039077 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-340-3p | MIMAT0000750 | MIRT043850 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044708 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT047761 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT050632 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
