HCSGD entry for PDE2A

1. General information

Official gene symbolPDE2A
Entrez ID5138
Gene full namephosphodiesterase 2A, cGMP-stimulated
Other gene symbolsCGS-PDE PDE2A1 PED2A4 cGSPDE
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0004112Cyclic-nucleotide phosphodiesterase activityIDAmolecular_function
GO:00041143',5'-cyclic-nucleotide phosphodiesterase activityIEAmolecular_function
GO:0004118CGMP-stimulated cyclic-nucleotide phosphodiesterase activityIDAmolecular_function
GO:0005262Calcium channel activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005759Mitochondrial matrixISScellular_component
GO:0005783Endoplasmic reticulumISScellular_component
GO:0005794Golgi apparatusISScellular_component
GO:0005829CytosolIDA TAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0006198CAMP catabolic processIDA IMPbiological_process
GO:0006626Protein targeting to mitochondrionISSbiological_process
GO:0006812Cation transportTASbiological_process
GO:0007165Signal transductionIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008144Drug bindingIDA IPImolecular_function
GO:0008152Metabolic processIDAbiological_process
GO:0019933CAMP-mediated signalingIMPbiological_process
GO:0019934CGMP-mediated signalingIMPbiological_process
GO:0030001Metal ion transportTASbiological_process
GO:0030224Monocyte differentiationIEPbiological_process
GO:0030424AxonIEAcellular_component
GO:0030425DendriteIEAcellular_component
GO:0030552CAMP bindingIMPmolecular_function
GO:0030553CGMP bindingIDA IMPmolecular_function
GO:0030818Negative regulation of cAMP biosynthetic processISSbiological_process
GO:0030911TPR domain bindingIPImolecular_function
GO:0033159Negative regulation of protein import into nucleus, translocationIDAbiological_process
GO:0034220Ion transmembrane transportTASbiological_process
GO:0035690Cellular response to drugIEP IMPbiological_process
GO:0036006Cellular response to macrophage colony-stimulating factor stimulusIDAbiological_process
GO:0042734Presynaptic membraneISScellular_component
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0043116Negative regulation of vascular permeabilityIMPbiological_process
GO:0043117Positive regulation of vascular permeabilityIMPbiological_process
GO:0046069CGMP catabolic processIDAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0050729Positive regulation of inflammatory responseISSbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0061028Establishment of endothelial barrierISSbiological_process
GO:0070588Calcium ion transmembrane transportTASbiological_process
GO:0071260Cellular response to mechanical stimulusISSbiological_process
GO:0071321Cellular response to cGMPIDAbiological_process
GO:0071560Cellular response to transforming growth factor beta stimulusIEPbiological_process
GO:0072511Divalent inorganic cation transportTASbiological_process
GO:0097011Cellular response to granulocyte macrophage colony-stimulating factor stimulusIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.20910872310.92283258990.88089761681.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2452550976
GSE13712_SHEARUp0.1445941312
GSE13712_STATICDown-0.4928038289
GSE19018Up0.2645731672
GSE19899_A1Up0.0112972753
GSE19899_A2Up0.1631537891
PubMed_21979375_A1Up0.4916402629
PubMed_21979375_A2Up0.1296080665
GSE35957Up0.0300097810
GSE36640Up0.1453870885
GSE54402Up0.3860526428
GSE9593Up0.1987073984
GSE43922Up0.0188496447
GSE24585Down-0.0506752636
GSE37065Up0.1270383052
GSE28863_A1Up0.0194478595
GSE28863_A2Up0.0152170962
GSE28863_A3Up0.2502734872
GSE28863_A4Up0.0286190461
GSE48662Down-0.2853740176

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Cyclic Guanosine MonophosphateDB02315 EXPT02518 | DB04536
ND7001DB05142 -
3-isobutyl-1-methyl-7H-xanthineDB07954 -
TofisopamDB08811 -
ND7001DB05142 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-192-5pMIMAT0000222MIRT004169MicroarrayFunctional MTI (Weak)16822819
hsa-miR-335-5pMIMAT0000765MIRT017522MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.