HCSGD entry for ATRAID
1. General information
| Official gene symbol | ATRAID |
|---|---|
| Entrez ID | 51374 |
| Gene full name | all-trans retinoic acid-induced differentiation factor |
| Other gene symbols | APR--3 APR-3 APR3 C2orf28 PRO240 p18 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003674 | Molecular_function | ND | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005635 | Nuclear envelope | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0010468 | Regulation of gene expression | IDA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0030154 | Cell differentiation | IEA | biological_process |
| GO:0030501 | Positive regulation of bone mineralization | IDA | biological_process |
| GO:0033689 | Negative regulation of osteoblast proliferation | IDA | biological_process |
| GO:0045669 | Positive regulation of osteoblast differentiation | IDA | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
| GO:2000599 | Negative regulation of cyclin catabolic process | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8443586452 | 0.0377884085 | 0.9999902473 | 0.3664513812 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3474159487 |
| GSE13712_SHEAR | Down | -0.2269916244 |
| GSE13712_STATIC | Down | -0.3124526377 |
| GSE19018 | Up | 0.3241752457 |
| GSE19899_A1 | Down | -1.0991224664 |
| GSE19899_A2 | Down | -0.1070140080 |
| PubMed_21979375_A1 | Down | -0.4479079067 |
| PubMed_21979375_A2 | Down | -0.4076572109 |
| GSE35957 | Down | -0.2397647210 |
| GSE36640 | Up | 0.4734398186 |
| GSE54402 | Down | -0.4449927711 |
| GSE9593 | Up | 0.0389433613 |
| GSE43922 | Down | -0.3005811577 |
| GSE24585 | Down | -0.3443471854 |
| GSE37065 | Up | 0.1545801420 |
| GSE28863_A1 | Up | 0.2542586921 |
| GSE28863_A2 | Up | 0.2856467202 |
| GSE28863_A3 | Down | -0.7257784327 |
| GSE28863_A4 | Down | -0.2708449696 |
| GSE48662 | Down | -0.0479909402 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-328-3p | MIMAT0000752 | MIRT043815 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26934949 | Apr3 accelerates the senescence of human retinal pigment epithelial cells |
| 26934949 | Apoptosis related protein 3 (Apr3) was originally cloned from HL60 cells induced by alltrans retinoic acid (ATRA) |
| 26934949 | Preliminary data revealed elevated Apr3 expression in the tissues of aged mice, suggesting that it is involved in the aging process |
| 26934949 | The present study demonstrated that Apr3 mRNA and protein levels were markedly increased in aged mouse RPE cells |
| 26934949 | Elevated Apr3 expression was also observed during premature senescence induced by oxidative stress (H2O2 and tertBHP) in ARPE19 cells |
| 26934949 | Moreover, Apr3 overexpression promoted cellular senescence in ARPE19 cells, as characterized by enhanced senescenceassociated betagalactosidase activity, reduced cell proliferation and increased expression of the senescence markers p53 and p21 |
| 26934949 | In addition, it was demonstrated that overexpression of Apr3N, a truncated counterpart of Apr3, abrogated Apr3induced phenotypes |
| 26934949 | It was concluded that Apr3 expression was induced in replicative and premature senescence of RPE cells and its overexpression accelerated senescence of ARPE19 cells, which provides important insights into the function of Apr3 in senescenceassociated diseases |
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