HCSGD entry for PDE1C

1. General information

Official gene symbolPDE1C
Entrez ID5137
Gene full namephosphodiesterase 1C, calmodulin-dependent 70kDa
Other gene symbolsHcam3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004117Calmodulin-dependent cyclic-nucleotide phosphodiesterase activityTASmolecular_function
GO:0005516Calmodulin bindingIEAmolecular_function
GO:0005829CytosolTAScellular_component
GO:0007165Signal transductionTASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007202Activation of phospholipase C activityTASbiological_process
GO:0008152Metabolic processTASbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.09654782110.01314424220.64910222220.2256814090

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.6375908615
GSE13712_SHEARUp0.5679956400
GSE13712_STATICUp1.1166424369
GSE19018Down-0.4873127016
GSE19899_A1Down-0.0942944744
GSE19899_A2Down-1.1541218171
PubMed_21979375_A1Down-1.4618696263
PubMed_21979375_A2Down-1.0052123480
GSE35957Up1.4302433618
GSE36640Up1.3978798605
GSE54402Down-0.6442915133
GSE9593Up0.5362275720
GSE43922Down-1.9817425191
GSE24585Down-0.0216483524
GSE37065Down-0.5882054933
GSE28863_A1Down-0.2201541359
GSE28863_A2Up0.7577211664
GSE28863_A3Down-0.4077043293
GSE28863_A4Up0.0580170078
GSE48662Up0.5751751415

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26464516PDE1C levels were increased in lung and aorta
26464516Senescent human VSMC showed elevated PDE1A and PDE1C and PDE5 mRNA levels (11
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