HCSGD entry for MBTPS2


1. General information

Official gene symbolMBTPS2
Entrez ID51360
Gene full namemembrane-bound transcription factor peptidase, site 2
Other gene symbolsBRESEK IFAP KFSDX S2P
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneTAScellular_component
GO:0004222Metalloendopeptidase activityIEAmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0006508ProteolysisIEAbiological_process
GO:0006987Activation of signaling protein activity involved in unfolded protein responseTASbiological_process
GO:0008203Cholesterol metabolic processIEAbiological_process
GO:0016020MembraneIEAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0030968Endoplasmic reticulum unfolded protein responseTASbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.67596682500.61020157670.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1322731095
GSE13712_SHEARUp0.0505116480
GSE13712_STATICDown-0.0303800784
GSE19018Down-0.0058471805
GSE19899_A1Down-0.1939556276
GSE19899_A2Down-0.3561285653
PubMed_21979375_A1Up0.0046659741
PubMed_21979375_A2Down-0.1558155708
GSE35957Up0.2713726725
GSE36640Up0.4874468139
GSE54402Down-0.1373445684
GSE9593Up0.1937525207
GSE43922Down-0.1595199188
GSE24585Down-0.0576186264
GSE37065Up0.1638447339
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Up0.2833774994

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1226-3pMIMAT0005577MIRT036430CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.