HCSGD entry for DACT1

1. General information

Official gene symbolDACT1
Entrez ID51339
Gene full namedishevelled-binding antagonist of beta-catenin 1
Other gene symbolsDAPPER DAPPER1 DPR1 FRODO HDPR1 THYEX3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0001702Gastrulation with mouth forming secondIEAbiological_process
GO:0005080Protein kinase C bindingISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0008013Beta-catenin bindingIDAmolecular_function
GO:0016055Wnt signaling pathwayIEAbiological_process
GO:0030054Cell junctionIEAcellular_component
GO:0030177Positive regulation of Wnt signaling pathwayIDAbiological_process
GO:0030178Negative regulation of Wnt signaling pathwayIDA IGI IMPbiological_process
GO:0030877Beta-catenin destruction complexIDAcellular_component
GO:0031647Regulation of protein stabilityIDAbiological_process
GO:0035412Regulation of catenin import into nucleusIMPbiological_process
GO:0035413Positive regulation of catenin import into nucleusIMPbiological_process
GO:0045202SynapseIEAcellular_component
GO:0045600Positive regulation of fat cell differentiationIEAbiological_process
GO:0045732Positive regulation of protein catabolic processIDAbiological_process
GO:0046329Negative regulation of JNK cascadeIDAbiological_process
GO:0048619Embryonic hindgut morphogenesisISSbiological_process
GO:0048813Dendrite morphogenesisIEAbiological_process
GO:0050808Synapse organizationIEAbiological_process
GO:0051018Protein kinase A bindingIDAmolecular_function
GO:0070097Delta-catenin bindingISSmolecular_function
GO:0090090Negative regulation of canonical Wnt signaling pathwayIEAbiological_process
GO:1900107Regulation of nodal signaling pathwayIDAbiological_process
GO:2000095Regulation of Wnt signaling pathway, planar cell polarity pathwayIEA ISSbiological_process
GO:2000134Negative regulation of G1/S transition of mitotic cell cycleIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.14012936820.00596397170.75241384870.1560414513

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.7694578442
GSE13712_SHEARDown-0.0221342707
GSE13712_STATICDown-0.3393678206
GSE19018Down-1.9553424648
GSE19899_A1Down-0.8476366198
GSE19899_A2Up0.0477280336
PubMed_21979375_A1Down-1.0358367118
PubMed_21979375_A2Up0.0457010690
GSE35957Up1.2879773688
GSE36640Up0.6615544128
GSE54402Up2.0139959655
GSE9593Down-0.1202351221
GSE43922Up0.0502987058
GSE24585Down-0.4025809293
GSE37065Down-0.5747803661
GSE28863_A1Down-0.1694780895
GSE28863_A2Down-0.6463431873
GSE28863_A3Up0.4251573459
GSE28863_A4Down-0.1079892006
GSE48662Down-0.1911853241

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018275MicroarrayFunctional MTI (Weak)18185580
hsa-miR-124-3pMIMAT0000422MIRT022775MicroarrayFunctional MTI (Weak)18668037
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.