HCSGD entry for WAC
1. General information
| Official gene symbol | WAC |
|---|---|
| Entrez ID | 51322 |
| Gene full name | WW domain containing adaptor with coiled-coil |
| Other gene symbols | BM-016 PRO1741 Wwp4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000993 | RNA polymerase II core binding | IDA | molecular_function |
| GO:0003682 | Chromatin binding | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | TAS | cellular_component |
| GO:0005681 | Spliceosomal complex | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | IMP | biological_process |
| GO:0010390 | Histone monoubiquitination | IMP | biological_process |
| GO:0016239 | Positive regulation of macroautophagy | IMP | biological_process |
| GO:0016607 | Nuclear speck | IEA | cellular_component |
| GO:0032435 | Negative regulation of proteasomal ubiquitin-dependent protein catabolic process | IMP | biological_process |
| GO:0044783 | G1 DNA damage checkpoint | IMP | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IMP | biological_process |
| GO:0071894 | Histone H2B conserved C-terminal lysine ubiquitination | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8605818358 | 0.4132589567 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0404333186 |
| GSE13712_SHEAR | Down | -0.2281674378 |
| GSE13712_STATIC | Down | -0.0593332755 |
| GSE19018 | Up | 0.1714245174 |
| GSE19899_A1 | Down | -0.1776247180 |
| GSE19899_A2 | Down | -0.1253585107 |
| PubMed_21979375_A1 | Down | -0.3249474023 |
| PubMed_21979375_A2 | Down | -0.3094120056 |
| GSE35957 | Down | -0.0861616908 |
| GSE36640 | Down | -0.1008581925 |
| GSE54402 | Up | 0.0017213691 |
| GSE9593 | Down | -0.0106823444 |
| GSE43922 | Down | -0.0409139136 |
| GSE24585 | Up | 0.2057827377 |
| GSE37065 | Up | 0.0418627885 |
| GSE28863_A1 | Up | 0.2048242570 |
| GSE28863_A2 | Up | 0.1541444905 |
| GSE28863_A3 | Down | -0.1582848579 |
| GSE28863_A4 | Up | 0.2091875937 |
| GSE48662 | Down | -0.0790803306 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-484 | MIMAT0002174 | MIRT042156 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18b-5p | MIMAT0001412 | MIRT042412 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-15b-5p | MIMAT0000417 | MIRT046410 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT048913 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-20a-5p | MIMAT0000075 | MIRT050624 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-5p | MIMAT0000072 | MIRT050717 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT051026 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
