HCSGD entry for WAC


1. General information

Official gene symbolWAC
Entrez ID51322
Gene full nameWW domain containing adaptor with coiled-coil
Other gene symbolsBM-016 PRO1741 Wwp4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000993RNA polymerase II core bindingIDAmolecular_function
GO:0003682Chromatin bindingIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusTAScellular_component
GO:0005681Spliceosomal complexIEAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006974Cellular response to DNA damage stimulusIMPbiological_process
GO:0010390Histone monoubiquitinationIMPbiological_process
GO:0016239Positive regulation of macroautophagyIMPbiological_process
GO:0016607Nuclear speckIEAcellular_component
GO:0032435Negative regulation of proteasomal ubiquitin-dependent protein catabolic processIMPbiological_process
GO:0044783G1 DNA damage checkpointIMPbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIMPbiological_process
GO:0071894Histone H2B conserved C-terminal lysine ubiquitinationIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.86058183580.41325895670.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0404333186
GSE13712_SHEARDown-0.2281674378
GSE13712_STATICDown-0.0593332755
GSE19018Up0.1714245174
GSE19899_A1Down-0.1776247180
GSE19899_A2Down-0.1253585107
PubMed_21979375_A1Down-0.3249474023
PubMed_21979375_A2Down-0.3094120056
GSE35957Down-0.0861616908
GSE36640Down-0.1008581925
GSE54402Up0.0017213691
GSE9593Down-0.0106823444
GSE43922Down-0.0409139136
GSE24585Up0.2057827377
GSE37065Up0.0418627885
GSE28863_A1Up0.2048242570
GSE28863_A2Up0.1541444905
GSE28863_A3Down-0.1582848579
GSE28863_A4Up0.2091875937
GSE48662Down-0.0790803306

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-484MIMAT0002174MIRT042156CLASHFunctional MTI (Weak)23622248
hsa-miR-18b-5pMIMAT0001412MIRT042412CLASHFunctional MTI (Weak)23622248
hsa-miR-15b-5pMIMAT0000417MIRT046410CLASHFunctional MTI (Weak)23622248
hsa-miR-93-5pMIMAT0000093MIRT048913CLASHFunctional MTI (Weak)23622248
hsa-miR-20a-5pMIMAT0000075MIRT050624CLASHFunctional MTI (Weak)23622248
hsa-miR-18a-5pMIMAT0000072MIRT050717CLASHFunctional MTI (Weak)23622248
hsa-miR-17-5pMIMAT0000070MIRT051026CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.