HCSGD entry for PCSK2

1. General information

Official gene symbolPCSK2
Entrez ID5126
Gene full nameproprotein convertase subtilisin/kexin type 2
Other gene symbolsNEC 2 NEC-2 NEC2 PC2 SPC2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004252Serine-type endopeptidase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005615Extracellular spaceIDAcellular_component
GO:0006508ProteolysisIDAbiological_process
GO:0007399Nervous system developmentIEAbiological_process
GO:0009790Embryo developmentIEAbiological_process
GO:0016020MembraneIDAcellular_component
GO:0016540Protein autoprocessingIEAbiological_process
GO:0030070Insulin processingIDAbiological_process
GO:0030133Transport vesicleIEAcellular_component
GO:0030425DendriteIEAcellular_component
GO:0032403Protein complex bindingIEAmolecular_function
GO:0034230Enkephalin processingISSbiological_process
GO:0034231Islet amyloid polypeptide processingISSbiological_process
GO:0034774Secretory granule lumenTAScellular_component
GO:0043204PerikaryonIEAcellular_component
GO:0044267Cellular protein metabolic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.91002664030.26114943580.99999024730.9806982879

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1029966424
GSE13712_SHEARDown-0.2210142992
GSE13712_STATICDown-0.1289645881
GSE19018Down-0.0006771793
GSE19899_A1Up0.0764744571
GSE19899_A2Down-0.2461305456
PubMed_21979375_A1Down-0.1537672141
PubMed_21979375_A2Down-0.0401883246
GSE35957Down-0.0018807280
GSE36640Down-0.0395350533
GSE54402Up0.0179742481
GSE9593Down-1.0766520586
GSE43922Up0.0242141093
GSE24585Down-0.0532658092
GSE37065Down-0.0699707381
GSE28863_A1Down-0.0724295094
GSE28863_A2Down-0.0552497909
GSE28863_A3Up0.2920170505
GSE28863_A4Up0.0201687409
GSE48662Up0.0040449844

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Insulin PorkDB00071 BTD00031 | BIOD00031

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.