HCSGD entry for GP6
1. General information
| Official gene symbol | GP6 |
|---|---|
| Entrez ID | 51206 |
| Gene full name | glycoprotein VI (platelet) |
| Other gene symbols | BDPLT11 GPIV GPVI |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004872 | Receptor activity | TAS | molecular_function |
| GO:0004888 | Transmembrane signaling receptor activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005518 | Collagen binding | IEA TAS | molecular_function |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | IEA | cellular_component |
| GO:0007167 | Enzyme linked receptor protein signaling pathway | TAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0030168 | Platelet activation | NAS TAS | biological_process |
| GO:0050900 | Leukocyte migration | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5948142206 | 0.7046797842 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0296227678 |
| GSE13712_SHEAR | Down | -0.0982175273 |
| GSE13712_STATIC | Down | -0.0279470444 |
| GSE19018 | Up | 0.0130672060 |
| GSE19899_A1 | Up | 0.0347704527 |
| GSE19899_A2 | Down | -0.1185598536 |
| PubMed_21979375_A1 | Down | -0.0077378736 |
| PubMed_21979375_A2 | Down | -0.0249498197 |
| GSE35957 | Up | 0.1259964745 |
| GSE36640 | Up | 0.0484665799 |
| GSE54402 | Up | 0.1619717180 |
| GSE9593 | Down | -0.0278574763 |
| GSE43922 | Up | 0.0973694419 |
| GSE24585 | Down | -0.2211116084 |
| GSE37065 | Down | -0.0105924479 |
| GSE28863_A1 | Down | -0.1190854977 |
| GSE28863_A2 | Down | -0.0350685287 |
| GSE28863_A3 | Up | 0.4282035997 |
| GSE28863_A4 | Up | 0.0606579687 |
| GSE48662 | Down | -0.0267927658 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 12353083 | Collagen response and glycoprotein VI function decline progressively as canine platelets age in vivo |
| 12353083 | Experiments with convulxin, a specific agonist for the collagen receptor glycoprotein VI (GPVI), also demonstrate an age-dependent decline in activation and the appearance of a non-reactive, aged population as observed with native collagens |
| 12353083 | Transfusion of biotinylated platelets from control dogs into dog #428 showed that the expected changes in collagen response and GPVI function did not occur in the transfused platelets |
| 12353083 | These observations demonstrate that the canine platelet response towards collagen is strongly dependent upon cell-age and suggest that this functional decline is at least partly due to an extrinsic-mediated alteration, possibly proteolytic, of GPVI |
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