HCSGD entry for CRBN
1. General information
| Official gene symbol | CRBN |
|---|---|
| Entrez ID | 51185 |
| Gene full name | cereblon |
| Other gene symbols | MRT2 MRT2A |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004176 | ATP-dependent peptidase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0016567 | Protein ubiquitination | IEA IMP | biological_process |
| GO:0031464 | Cul4A-RING ubiquitin ligase complex | IDA | cellular_component |
| GO:0032463 | Negative regulation of protein homooligomerization | IEA | biological_process |
| GO:0034766 | Negative regulation of ion transmembrane transport | IEA | biological_process |
| GO:0043161 | Proteasome-mediated ubiquitin-dependent protein catabolic process | IMP | biological_process |
| GO:0090073 | Positive regulation of protein homodimerization activity | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1269639109 | 0.7050320657 | 0.7256204733 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3561079382 |
| GSE13712_SHEAR | Down | -0.3464145652 |
| GSE13712_STATIC | Down | -0.4404473286 |
| GSE19018 | Up | 0.2112236993 |
| GSE19899_A1 | Down | -0.0192857453 |
| GSE19899_A2 | Up | 0.1239911934 |
| PubMed_21979375_A1 | Up | 0.2060496290 |
| PubMed_21979375_A2 | Up | 0.6954118927 |
| GSE35957 | Up | 0.1064559456 |
| GSE36640 | Up | 0.2808681532 |
| GSE54402 | Down | -0.2450037363 |
| GSE9593 | Up | 0.4576442971 |
| GSE43922 | Up | 0.0045976347 |
| GSE24585 | Up | 0.3694043385 |
| GSE37065 | Up | 0.0463054416 |
| GSE28863_A1 | Up | 0.4825048604 |
| GSE28863_A2 | Up | 0.1271587103 |
| GSE28863_A3 | Down | -0.2982605770 |
| GSE28863_A4 | Down | -0.2180811548 |
| GSE48662 | Up | 0.2550294960 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049014 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
