HCSGD entry for CYB5R4
1. General information
| Official gene symbol | CYB5R4 |
|---|---|
| Entrez ID | 51167 |
| Gene full name | cytochrome b5 reductase 4 |
| Other gene symbols | NCB5OR RP4-676J13.1 cb5/cb5R dJ676J13.1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003032 | Detection of oxygen | NAS | biological_process |
| GO:0003958 | NADPH-hemoprotein reductase activity | IEA | molecular_function |
| GO:0004128 | Cytochrome-b5 reductase activity, acting on NAD(P)H | IDA | molecular_function |
| GO:0005783 | Endoplasmic reticulum | IDA | cellular_component |
| GO:0006091 | Generation of precursor metabolites and energy | IDA | biological_process |
| GO:0006739 | NADP metabolic process | IEA | biological_process |
| GO:0006801 | Superoxide metabolic process | IDA | biological_process |
| GO:0016174 | NAD(P)H oxidase activity | IDA | molecular_function |
| GO:0016653 | Oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor | IDA | molecular_function |
| GO:0020037 | Heme binding | IEA | molecular_function |
| GO:0030073 | Insulin secretion | ISS | biological_process |
| GO:0042593 | Glucose homeostasis | ISS | biological_process |
| GO:0046677 | Response to antibiotic | ISS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0048468 | Cell development | ISS | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0050660 | Flavin adenine dinucleotide binding | IEA | molecular_function |
| GO:0055114 | Oxidation-reduction process | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4563804529 | 0.2542537442 | 0.9999902473 | 0.9669430429 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0398997337 |
| GSE13712_SHEAR | Up | 0.2761255617 |
| GSE13712_STATIC | Up | 0.1695566223 |
| GSE19018 | Down | -0.3259621455 |
| GSE19899_A1 | Down | -0.1690924872 |
| GSE19899_A2 | Up | 0.1203548467 |
| PubMed_21979375_A1 | Up | 0.5329242828 |
| PubMed_21979375_A2 | Up | 0.2807590853 |
| GSE35957 | Down | -0.2569718582 |
| GSE36640 | Down | -0.2391563457 |
| GSE54402 | Up | 0.6941631404 |
| GSE9593 | Up | 0.0744968221 |
| GSE43922 | Down | -0.0587110361 |
| GSE24585 | Down | -0.0642171849 |
| GSE37065 | Up | 0.2410315466 |
| GSE28863_A1 | Down | -0.2688935011 |
| GSE28863_A2 | Up | 0.3561894577 |
| GSE28863_A3 | Down | -0.3745087212 |
| GSE28863_A4 | Down | -0.2751243738 |
| GSE48662 | Down | -0.4645024055 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-373-3p | MIMAT0000726 | MIRT004438 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-148b-3p | MIMAT0000759 | MIRT019387 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029327 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-373-3p | MIMAT0000726 | NA | hsa-miR-373 | 15685193 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
