HCSGD entry for AADAT
1. General information
| Official gene symbol | AADAT |
|---|---|
| Entrez ID | 51166 |
| Gene full name | aminoadipate aminotransferase |
| Other gene symbols | KAT2 KATII |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003824 | Catalytic activity | IEA | molecular_function |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005759 | Mitochondrial matrix | TAS | cellular_component |
| GO:0006103 | 2-oxoglutarate metabolic process | IDA | biological_process |
| GO:0006536 | Glutamate metabolic process | IDA | biological_process |
| GO:0006554 | Lysine catabolic process | TAS | biological_process |
| GO:0006569 | Tryptophan catabolic process | TAS | biological_process |
| GO:0009058 | Biosynthetic process | IEA | biological_process |
| GO:0016212 | Kynurenine-oxoglutarate transaminase activity | IDA TAS | molecular_function |
| GO:0019441 | Tryptophan catabolic process to kynurenine | IEA | biological_process |
| GO:0030170 | Pyridoxal phosphate binding | IEA | molecular_function |
| GO:0033512 | L-lysine catabolic process to acetyl-CoA via saccharopine | IEA | biological_process |
| GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0042803 | Protein homodimerization activity | IPI | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0047536 | 2-aminoadipate transaminase activity | EXP IDA | molecular_function |
| GO:0070189 | Kynurenine metabolic process | IDA | biological_process |
| GO:0097052 | L-kynurenine metabolic process | IDA TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9826294936 | 0.0041208199 | 0.9999902473 | 0.1306796386 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0745037548 |
| GSE13712_SHEAR | Down | -0.2882025434 |
| GSE13712_STATIC | Down | -0.8315390906 |
| GSE19018 | Down | -0.6093901622 |
| GSE19899_A1 | Down | -0.0844971605 |
| GSE19899_A2 | Down | -0.3184276203 |
| PubMed_21979375_A1 | Down | -0.7978465117 |
| PubMed_21979375_A2 | Up | 0.2088217348 |
| GSE35957 | Down | -0.2575126515 |
| GSE36640 | Down | -1.8873620128 |
| GSE54402 | Up | 0.6620839275 |
| GSE9593 | Down | -0.4393159640 |
| GSE43922 | Down | -0.1546948879 |
| GSE24585 | Down | -0.4209049150 |
| GSE37065 | Down | -0.1541917407 |
| GSE28863_A1 | Down | -0.0706388350 |
| GSE28863_A2 | Down | -0.5023728951 |
| GSE28863_A3 | Down | -0.3375839546 |
| GSE28863_A4 | Down | -0.3284098152 |
| GSE48662 | Down | -0.6204329850 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| L-Glutamic Acid | DB00142 | NUTR00027 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-103a-3p | MIMAT0000101 | MIRT027084 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031647 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
