HCSGD entry for INSIG2
1. General information
| Official gene symbol | INSIG2 |
|---|---|
| Entrez ID | 51141 |
| Gene full name | insulin induced gene 2 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0006641 | Triglyceride metabolic process | IEA | biological_process |
| GO:0006695 | Cholesterol biosynthetic process | IEA | biological_process |
| GO:0008134 | Transcription factor binding | IEA | molecular_function |
| GO:0010894 | Negative regulation of steroid biosynthetic process | IEA | biological_process |
| GO:0032868 | Response to insulin | IEA | biological_process |
| GO:0032933 | SREBP signaling pathway | IDA | biological_process |
| GO:0032937 | SREBP-SCAP-Insig complex | IDA | cellular_component |
| GO:0042472 | Inner ear morphogenesis | IEA | biological_process |
| GO:0042474 | Middle ear morphogenesis | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045717 | Negative regulation of fatty acid biosynthetic process | IEA | biological_process |
| GO:0060021 | Palate development | IEA | biological_process |
| GO:0060363 | Cranial suture morphogenesis | IEA | biological_process |
| GO:0070542 | Response to fatty acid | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0182634322 | 0.4104914441 | 0.3303861168 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.3961640991 |
| GSE13712_SHEAR | Down | -0.0748779179 |
| GSE13712_STATIC | Down | -0.1501277590 |
| GSE19018 | Up | 1.1117619188 |
| GSE19899_A1 | Up | 0.6450302097 |
| GSE19899_A2 | Up | 0.0804190386 |
| PubMed_21979375_A1 | Up | 0.0620887242 |
| PubMed_21979375_A2 | Up | 0.6494161710 |
| GSE35957 | Down | -0.0181319612 |
| GSE36640 | Up | 0.1916701217 |
| GSE54402 | Up | 0.1293305223 |
| GSE9593 | Up | 0.5146158726 |
| GSE43922 | Up | 0.6022951719 |
| GSE24585 | Up | 0.0218566947 |
| GSE37065 | Up | 0.4091276394 |
| GSE28863_A1 | Up | 0.1907190572 |
| GSE28863_A2 | Up | 1.0223492422 |
| GSE28863_A3 | Down | -0.2695591753 |
| GSE28863_A4 | Down | -0.3900604764 |
| GSE48662 | Up | 0.0160910622 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-373-3p | MIMAT0000726 | MIRT002529 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT017795 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-375 | MIMAT0000728 | MIRT019869 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-142-3p | MIMAT0000434 | MIRT021575 | Microarray | Functional MTI (Weak) | 17612493 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-373-3p | MIMAT0000726 | NA | hsa-miR-373 | 15685193 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23500545 | The mechanisms by which oxysterols may influence proliferation are manifold: they control the transcription and the turnover of the key enzyme in cholesterol synthesis, 3-hydroxy-3-methylglutaryl CoA reductase, by binding to Insig-1, Insig-2 and liver X receptors |
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