HCSGD entry for APH1A
1. General information
| Official gene symbol | APH1A |
|---|---|
| Entrez ID | 51107 |
| Gene full name | APH1A gamma secretase subunit |
| Other gene symbols | 6530402N02Rik APH-1 APH-1A CGI-78 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001656 | Metanephros development | IEA | biological_process |
| GO:0004175 | Endopeptidase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005783 | Endoplasmic reticulum | IDA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | IEA | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | IDA | cellular_component |
| GO:0006509 | Membrane protein ectodomain proteolysis | IDA | biological_process |
| GO:0007219 | Notch signaling pathway | TAS | biological_process |
| GO:0007220 | Notch receptor processing | IMP TAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016485 | Protein processing | IDA IEA | biological_process |
| GO:0031293 | Membrane protein intracellular domain proteolysis | IMP TAS | biological_process |
| GO:0032580 | Golgi cisterna membrane | IEA | cellular_component |
| GO:0042987 | Amyloid precursor protein catabolic process | IMP TAS | biological_process |
| GO:0043065 | Positive regulation of apoptotic process | TAS | biological_process |
| GO:0043085 | Positive regulation of catalytic activity | IDA IEA | biological_process |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0097190 | Apoptotic signaling pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9758922457 | 0.0469472284 | 0.9999902473 | 0.4068630349 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1171891627 |
| GSE13712_SHEAR | Down | -0.1262036742 |
| GSE13712_STATIC | Down | -0.2209671705 |
| GSE19018 | Up | 0.0825676535 |
| GSE19899_A1 | Down | -0.3868154135 |
| GSE19899_A2 | Down | -0.0662343268 |
| PubMed_21979375_A1 | Down | -0.2622506102 |
| PubMed_21979375_A2 | Down | -1.6745030377 |
| GSE35957 | Down | -0.2737919863 |
| GSE36640 | Down | -0.1882305114 |
| GSE54402 | Up | 0.0035469982 |
| GSE9593 | Up | 0.0468079843 |
| GSE43922 | Up | 0.0265221214 |
| GSE24585 | Down | -0.0648398601 |
| GSE37065 | Down | -0.1864977962 |
| GSE28863_A1 | Down | -0.4637303244 |
| GSE28863_A2 | Up | 0.0313278799 |
| GSE28863_A3 | Down | -0.5380017485 |
| GSE28863_A4 | Down | -0.0959547085 |
| GSE48662 | Down | -0.0178505443 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| E2012 | DB05171 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-145-5p | MIMAT0000437 | MIRT021538 | Reporter assay;Microarray | Functional MTI | 21351259 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
