HCSGD entry for SEPSECS
1. General information
| Official gene symbol | SEPSECS |
|---|---|
| Entrez ID | 51091 |
| Gene full name | Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase |
| Other gene symbols | LP PCH2D SLA SLA/LP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000049 | TRNA binding | ISS | molecular_function |
| GO:0001514 | Selenocysteine incorporation | ISS | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | ISS | cellular_component |
| GO:0005737 | Cytoplasm | ISS | cellular_component |
| GO:0016740 | Transferase activity | IEA | molecular_function |
| GO:0016785 | Transferase activity, transferring selenium-containing groups | IEA | molecular_function |
| GO:0030170 | Pyridoxal phosphate binding | IEA | molecular_function |
| GO:0097056 | Selenocysteinyl-tRNA(Sec) biosynthetic process | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4697070096 | 0.2186259489 | 0.9999902473 | 0.8995585091 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0644849319 |
| GSE13712_SHEAR | Up | 0.5522205129 |
| GSE13712_STATIC | Up | 0.1822727165 |
| GSE19018 | Up | 0.1019405973 |
| GSE19899_A1 | Down | -0.0091325565 |
| GSE19899_A2 | Down | -0.2966531867 |
| PubMed_21979375_A1 | Up | 0.3590305195 |
| PubMed_21979375_A2 | Up | 0.0596778632 |
| GSE35957 | Down | -0.2541235150 |
| GSE36640 | Down | -0.2671599361 |
| GSE54402 | Down | -0.2756744970 |
| GSE9593 | Down | -0.1896240969 |
| GSE43922 | Up | 0.0334846644 |
| GSE24585 | Up | 0.6892371550 |
| GSE37065 | Up | 0.2183371556 |
| GSE28863_A1 | Up | 0.2483195137 |
| GSE28863_A2 | Down | -0.2776338695 |
| GSE28863_A3 | Down | -0.8592985359 |
| GSE28863_A4 | Down | -0.2653956973 |
| GSE48662 | Down | -0.1898403492 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-100-5p | MIMAT0000098 | MIRT048507 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
