HCSGD entry for PCK2
1. General information
| Official gene symbol | PCK2 |
|---|---|
| Entrez ID | 5106 |
| Gene full name | phosphoenolpyruvate carboxykinase 2 (mitochondrial) |
| Other gene symbols | PEPCK PEPCK-M PEPCK2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004611 | Phosphoenolpyruvate carboxykinase activity | IEA TAS | molecular_function |
| GO:0004613 | Phosphoenolpyruvate carboxykinase (GTP) activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0005739 | Mitochondrion | IEA TAS | cellular_component |
| GO:0005759 | Mitochondrial matrix | TAS | cellular_component |
| GO:0005975 | Carbohydrate metabolic process | TAS | biological_process |
| GO:0006006 | Glucose metabolic process | TAS | biological_process |
| GO:0006090 | Pyruvate metabolic process | IEA | biological_process |
| GO:0006094 | Gluconeogenesis | IEA TAS | biological_process |
| GO:0006107 | Oxaloacetate metabolic process | IEA | biological_process |
| GO:0006116 | NADH oxidation | IEA | biological_process |
| GO:0016301 | Kinase activity | IEA | molecular_function |
| GO:0032024 | Positive regulation of insulin secretion | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0051384 | Response to glucocorticoid | IEA | biological_process |
| GO:0071333 | Cellular response to glucose stimulus | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1444606664 | 0.0026993883 | 0.7618048478 | 0.1031552975 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.1102538145 |
| GSE13712_SHEAR | Up | 0.1849490713 |
| GSE13712_STATIC | Up | 0.1445895548 |
| GSE19018 | Up | 1.8071721347 |
| GSE19899_A1 | Down | -0.3496158250 |
| GSE19899_A2 | Down | -1.8519191799 |
| PubMed_21979375_A1 | Down | -1.6065785538 |
| PubMed_21979375_A2 | Down | -2.2366816012 |
| GSE35957 | Down | -1.0963719285 |
| GSE36640 | Down | -1.5938360824 |
| GSE54402 | Down | -0.9876505487 |
| GSE9593 | Up | 0.2439973818 |
| GSE43922 | Down | -0.3478034024 |
| GSE24585 | Up | 0.8599495291 |
| GSE37065 | Down | -0.6715528620 |
| GSE28863_A1 | Up | 0.0400912705 |
| GSE28863_A2 | Down | -0.3848619911 |
| GSE28863_A3 | Up | 0.3158545111 |
| GSE28863_A4 | Down | -0.0735977970 |
| GSE48662 | Up | 0.5209003958 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-24-3p | MIMAT0000080 | MIRT030573 | Microarray | Functional MTI (Weak) | 19748357 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031958 | Proteomics | Functional MTI (Weak) | 18668040 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
