HCSGD entry for GMNN
1. General information
| Official gene symbol | GMNN |
|---|---|
| Entrez ID | 51053 |
| Gene full name | geminin, DNA replication inhibitor |
| Other gene symbols | Gem |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0003714 | Transcription corepressor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006461 | Protein complex assembly | IEA | biological_process |
| GO:0008156 | Negative regulation of DNA replication | IDA IEA | biological_process |
| GO:0009887 | Organ morphogenesis | IEA | biological_process |
| GO:0042826 | Histone deacetylase binding | IPI | molecular_function |
| GO:0045786 | Negative regulation of cell cycle | IDA IEA | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IDA IEA | biological_process |
| GO:0070491 | Repressing transcription factor binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9825390525 | 0.0000650507 | 0.9999902473 | 0.0132728682 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.5516871083 |
| GSE13712_SHEAR | Up | 0.1047041817 |
| GSE13712_STATIC | Up | 0.0503835457 |
| GSE19018 | Down | -0.4500308526 |
| GSE19899_A1 | Down | -3.0281470180 |
| GSE19899_A2 | Down | -2.9099244575 |
| PubMed_21979375_A1 | Down | -2.2159295914 |
| PubMed_21979375_A2 | Down | -3.5611325697 |
| GSE35957 | Down | -3.2151426030 |
| GSE36640 | Down | -3.4041850271 |
| GSE54402 | Down | -0.6220705830 |
| GSE9593 | Down | -1.3558615304 |
| GSE43922 | Down | -1.1584295104 |
| GSE24585 | Up | 0.0910455559 |
| GSE37065 | Up | 0.4387969554 |
| GSE28863_A1 | Down | -0.1375069962 |
| GSE28863_A2 | Up | 0.9105455806 |
| GSE28863_A3 | Down | -0.0997274751 |
| GSE28863_A4 | Down | -0.0747562649 |
| GSE48662 | Down | -1.1466016353 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-449b-5p | MIMAT0003327 | MIRT006352 | Luciferase reporter assay//Western blot | Functional MTI | 21418558 |
| hsa-miR-449a | MIMAT0001541 | MIRT006345 | Luciferase reporter assay//Western blot | Functional MTI | 21418558 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016570 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029967 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043150 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23142824 | Reduced Geminin levels promote cellular senescence |
| 23142824 | Cdt1 is a central regulator of DNA replication licensing acting during the G1 phase and it is negatively controlled by Geminin |
| 23142824 | Here, we characterize the cell cycle expression pattern of Cdt1 and Geminin during successive passages of primary fibroblasts and compare it to tumour-derived cell lines |
| 23142824 | Cdt1 and Geminin are strictly expressed in distinct subpopulations of young fibroblasts, similarly to cancer cells, with Geminin accumulating shortly after the onset of S phase |
| 23142824 | Cdt1 and Geminin are down-regulated when primary human and mouse fibroblasts undergo replicative or stress-induced senescence |
| 23142824 | RNAi-mediated Geminin knock-down in human cells enhances the appearance of phenotypic and molecular features of senescence |
| 23142824 | Mouse embryonic fibroblasts heterozygous for Geminin exhibit accelerated senescence compared to control fibroblasts |
| 23142824 | In contrast, ectopic expression of Geminin in mouse embryonic fibroblasts delays the appearance of the senescent phenotype |
| 23142824 | Taken together, our data suggest that changes in Geminin expression levels affect the establishment of senescence pathways |
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