HCSGD entry for PCK1

1. General information

Official gene symbolPCK1
Entrez ID5105
Gene full namephosphoenolpyruvate carboxykinase 1 (soluble)
Other gene symbolsPEPCK-C PEPCK1 PEPCKC
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000287Magnesium ion bindingIDAmolecular_function
GO:0004611Phosphoenolpyruvate carboxykinase activityIEAmolecular_function
GO:0004613Phosphoenolpyruvate carboxykinase (GTP) activityIEA ISSmolecular_function
GO:0005525GTP bindingIDA IEAmolecular_function
GO:0005737CytoplasmISScellular_component
GO:0005829CytosolTAScellular_component
GO:0005975Carbohydrate metabolic processTASbiological_process
GO:0006006Glucose metabolic processIMP TASbiological_process
GO:0006094GluconeogenesisIEA ISS TASbiological_process
GO:0006107Oxaloacetate metabolic processIEAbiological_process
GO:0006475Internal protein amino acid acetylationIDAbiological_process
GO:0014823Response to activityIEAbiological_process
GO:0016301Kinase activityIEAmolecular_function
GO:0017144Drug metabolic processTASbiological_process
GO:0019003GDP bindingIEAmolecular_function
GO:0030145Manganese ion bindingIDAmolecular_function
GO:0031406Carboxylic acid bindingIDAmolecular_function
GO:0032868Response to insulinIDAbiological_process
GO:0042593Glucose homeostasisISSbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046327Glycerol biosynthetic process from pyruvateISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.46294388510.57724334180.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0290993909
GSE13712_SHEARDown-0.0850166135
GSE13712_STATICDown-0.1959445157
GSE19018Up0.0962877949
GSE19899_A1Up0.2022913707
GSE19899_A2Up0.0118146758
PubMed_21979375_A1Down-0.1060392087
PubMed_21979375_A2Down-0.0943993195
GSE35957Up0.3116387300
GSE36640Up0.0312303365
GSE54402Up0.0577387687
GSE9593Down-1.2792833336
GSE43922Up0.0246898671
GSE24585Up0.3195573604
GSE37065Up0.0420924916
GSE28863_A1Down-0.0040768058
GSE28863_A2Down-0.0522433010
GSE28863_A3Up0.1793335382
GSE28863_A4Up0.1596096933
GSE48662Down-0.0315392122

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

PhosphoenolpyruvateDB01819 EXPT02550
1-(2-Fluorobenzyl)-3-Butyl-8-(N-Acetyl-4-Aminobenzyl)-XanthineDB02008 EXPT01503
1-Allyl-3-Butyl-8-(N-Acetyl-4-Aminobenzyl)-XanthineDB03267 EXPT03126
Phosphomethylphosphonic Acid-Guanylate EsterDB03725 EXPT01659

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26631730In locomotory muscle of post-fertile Caenorhabditis elegans, we identified a progressive decrease in cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C), a longevity-associated metabolic enzyme, and a reciprocal increase in glycolytic pyruvate kinase (PK) that were necessary and sufficient to limit lifespan
26631730Decline in PEPCK-C with age also led to loss of cellular function and integrity including muscle activity, and cellular senescence
26631730Quantifications of metabolic flux show that reciprocal changes in PEPCK-C and PK with age shunted energy metabolism toward glycolysis, reducing mitochondrial bioenergetics
26631730Last, calorie restriction countered changes in PEPCK-C and PK with age to elicit anti-aging effects via TOR inhibition
26631730Thus, a programmed metabolic event involving PEPCK-C and PK is a determinant of aging that can be modified to modulate aging
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