HCSGD entry for EXOSC1
1. General information
| Official gene symbol | EXOSC1 |
|---|---|
| Entrez ID | 51013 |
| Gene full name | exosome component 1 |
| Other gene symbols | CGI-108 CSL4 Csl4p SKI4 Ski4p hCsl4p p13 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000178 | Exosome (RNase complex) | IDA IEA NAS | cellular_component |
| GO:0000288 | Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | TAS | biological_process |
| GO:0003723 | RNA binding | IEA NAS | molecular_function |
| GO:0004532 | Exoribonuclease activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006364 | RRNA processing | IEA | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0016071 | MRNA metabolic process | TAS | biological_process |
| GO:0043928 | Exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6066736598 | 0.7350207021 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2771509959 |
| GSE13712_SHEAR | Up | 0.1026546024 |
| GSE13712_STATIC | Up | 0.1239757483 |
| GSE19018 | Down | -0.0392787299 |
| GSE19899_A1 | Up | 0.1026857620 |
| GSE19899_A2 | Up | 0.1330745928 |
| PubMed_21979375_A1 | Down | -0.0741964102 |
| PubMed_21979375_A2 | Down | -0.0685988879 |
| GSE35957 | Down | -0.1504696056 |
| GSE36640 | Up | 0.0119084030 |
| GSE54402 | Up | 0.1487992945 |
| GSE9593 | Down | -0.0169115439 |
| GSE43922 | Up | 0.0812528959 |
| GSE24585 | Up | 0.0951459045 |
| GSE37065 | Down | -0.1082089459 |
| GSE28863_A1 | Down | -0.1693789888 |
| GSE28863_A2 | Down | -0.2681138470 |
| GSE28863_A3 | Down | -0.0050369073 |
| GSE28863_A4 | Up | 0.1624034949 |
| GSE48662 | Down | -0.2350052227 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-342-3p | MIMAT0000753 | MIRT043724 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046834 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT050366 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
