HCSGD entry for TPRKB
1. General information
| Official gene symbol | TPRKB |
|---|---|
| Entrez ID | 51002 |
| Gene full name | TP53RK binding protein |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | IDA | cellular_component |
| GO:0008033 | TRNA processing | IEA | biological_process |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
| GO:0030163 | Protein catabolic process | NAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9248799704 | 0.0090894495 | 0.9999902473 | 0.1887750197 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3091733033 |
| GSE13712_SHEAR | Down | -0.3366018261 |
| GSE13712_STATIC | Down | -0.3991449059 |
| GSE19018 | Down | -0.7362360497 |
| GSE19899_A1 | Up | 0.2435805423 |
| GSE19899_A2 | Down | -0.5328981911 |
| PubMed_21979375_A1 | Up | 0.0099923806 |
| PubMed_21979375_A2 | Down | -0.2128605699 |
| GSE35957 | Down | -0.8532357450 |
| GSE36640 | Down | -1.4432961314 |
| GSE54402 | Up | 0.2412105302 |
| GSE9593 | Down | -0.5731188982 |
| GSE43922 | Up | 0.0515067256 |
| GSE24585 | Down | -0.9791052396 |
| GSE37065 | Down | -0.0246197037 |
| GSE28863_A1 | Down | -0.0615149782 |
| GSE28863_A2 | Up | 0.3360777330 |
| GSE28863_A3 | Down | -0.5585475016 |
| GSE28863_A4 | Down | -0.1113874177 |
| GSE48662 | Down | -0.7007070649 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT020915 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029846 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT036857 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25822194 | Inactivation of KEOPS subunit Cgi121 specifically inhibits telomere recombination, and significantly extends cell longevity in both telomerase-positive and pre-senescing telomerase-negative cells |
| 25822194 | Deletion of CGI121 in the short-lived yku80(tel) mutant restores lifespan to cgi121Delta level, supporting the function of Cgi121 in telomeric single-stranded DNA generation and thus in promotion of telomere recombination |
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