HCSGD entry for ACOX1

1. General information

Official gene symbolACOX1
Entrez ID51
Gene full nameacyl-CoA oxidase 1, palmitoyl
Other gene symbolsACOX PALMCOX SCOX
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000038Very long-chain fatty acid metabolic processIMPbiological_process
GO:0003995Acyl-CoA dehydrogenase activityIEAmolecular_function
GO:0003997Acyl-CoA oxidase activityIDA IEA IGI IMP TASmolecular_function
GO:0005102Receptor bindingIPImolecular_function
GO:0005504Fatty acid bindingIEAmolecular_function
GO:0005739MitochondrionIEAcellular_component
GO:0005777PeroxisomeIDA IEAcellular_component
GO:0005778Peroxisomal membraneIEAcellular_component
GO:0005782Peroxisomal matrixTAScellular_component
GO:0006091Generation of precursor metabolites and energyIMPbiological_process
GO:0006629Lipid metabolic processIDAbiological_process
GO:0006631Fatty acid metabolic processIEAbiological_process
GO:0006635Fatty acid beta-oxidationIEAbiological_process
GO:0006693Prostaglandin metabolic processIMPbiological_process
GO:0007283SpermatogenesisIEAbiological_process
GO:0016401Palmitoyl-CoA oxidase activityIDA IEAmolecular_function
GO:0016559Peroxisome fissionIGIbiological_process
GO:0019395Fatty acid oxidationIGI IMPbiological_process
GO:0030165PDZ domain bindingIDAmolecular_function
GO:0033540Fatty acid beta-oxidation using acyl-CoA oxidaseIEA IMP TASbiological_process
GO:0033559Unsaturated fatty acid metabolic processTASbiological_process
GO:0036109Alpha-linolenic acid metabolic processTASbiological_process
GO:0044255Cellular lipid metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0047485Protein N-terminus bindingIPImolecular_function
GO:0050660Flavin adenine dinucleotide bindingIEAmolecular_function
GO:0055088Lipid homeostasisIDA IGIbiological_process
GO:0071949FAD bindingIDAmolecular_function
GO:2000189Positive regulation of cholesterol homeostasisIGIbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00810603320.99655482310.23343424511.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2724203831
GSE13712_SHEARUp0.2592825620
GSE13712_STATICUp0.3641119987
GSE19018Down-0.0567830309
GSE19899_A1Up0.0916619423
GSE19899_A2Up0.2561689600
PubMed_21979375_A1Up0.3357272450
PubMed_21979375_A2Up0.1747343226
GSE35957Up0.4892602286
GSE36640Up0.5843160520
GSE54402Up0.2655516998
GSE9593Down-0.0499584862
GSE43922Up0.1736677944
GSE24585Up0.9695182347
GSE37065Down-0.1849429917
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Up1.3861425086

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

(3R)-3-HYDROXYDODECANOIC ACIDDB07930 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-92b-5pMIMAT0004792MIRT037792CLASHFunctional MTI (Weak)23622248
hsa-miR-615-3pMIMAT0003283MIRT040279CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.