HCSGD entry for SHANK1
1. General information
| Official gene symbol | SHANK1 |
|---|---|
| Entrez ID | 50944 |
| Gene full name | SH3 and multiple ankyrin repeat domains 1 |
| Other gene symbols | SPANK-1 SSTRIP synamon |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005622 | Intracellular | NAS | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005886 | Plasma membrane | ISS | cellular_component |
| GO:0006461 | Protein complex assembly | ISS | biological_process |
| GO:0007016 | Cytoskeletal anchoring at plasma membrane | NAS | biological_process |
| GO:0007616 | Long-term memory | ISS | biological_process |
| GO:0008022 | Protein C-terminus binding | ISS | molecular_function |
| GO:0008306 | Associative learning | ISS | biological_process |
| GO:0008328 | Ionotropic glutamate receptor complex | ISS | cellular_component |
| GO:0016020 | Membrane | IDA | cellular_component |
| GO:0017124 | SH3 domain binding | ISS | molecular_function |
| GO:0017146 | N-methyl-D-aspartate selective glutamate receptor complex | ISS | cellular_component |
| GO:0030054 | Cell junction | IEA | cellular_component |
| GO:0030160 | GKAP/Homer scaffold activity | ISS | molecular_function |
| GO:0030425 | Dendrite | NAS | cellular_component |
| GO:0030534 | Adult behavior | IMP | biological_process |
| GO:0031877 | Somatostatin receptor binding | ISS | molecular_function |
| GO:0032232 | Negative regulation of actin filament bundle assembly | ISS | biological_process |
| GO:0032403 | Protein complex binding | ISS | molecular_function |
| GO:0035176 | Social behavior | IMP | biological_process |
| GO:0035255 | Ionotropic glutamate receptor binding | ISS | molecular_function |
| GO:0035418 | Protein localization to synapse | ISS | biological_process |
| GO:0042048 | Olfactory behavior | IEA | biological_process |
| GO:0042802 | Identical protein binding | ISS | molecular_function |
| GO:0043005 | Neuron projection | ISS | cellular_component |
| GO:0043197 | Dendritic spine | ISS | cellular_component |
| GO:0045211 | Postsynaptic membrane | ISS | cellular_component |
| GO:0046959 | Habituation | IEA | biological_process |
| GO:0050885 | Neuromuscular process controlling balance | ISS | biological_process |
| GO:0050894 | Determination of affect | IMP | biological_process |
| GO:0060013 | Righting reflex | IEA | biological_process |
| GO:0060074 | Synapse maturation | ISS | biological_process |
| GO:0060076 | Excitatory synapse | ISS | cellular_component |
| GO:0060997 | Dendritic spine morphogenesis | ISS | biological_process |
| GO:0060999 | Positive regulation of dendritic spine development | ISS | biological_process |
| GO:0071532 | Ankyrin repeat binding | ISS | molecular_function |
| GO:0071625 | Vocalization behavior | IMP | biological_process |
| GO:0097110 | Scaffold protein binding | ISS | molecular_function |
| GO:0097481 | Neuronal postsynaptic density | ISS | cellular_component |
| GO:2000311 | Regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity | ISS | biological_process |
| GO:2000463 | Positive regulation of excitatory postsynaptic membrane potential | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2569294632 | 0.9344468067 | 0.9500735918 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0423625328 |
| GSE13712_SHEAR | Up | 0.1248686391 |
| GSE13712_STATIC | Up | 0.2749057181 |
| GSE19018 | Down | -0.0669163175 |
| GSE19899_A1 | Down | -0.0541277333 |
| GSE19899_A2 | Up | 0.0208211396 |
| PubMed_21979375_A1 | Up | 0.0931575407 |
| PubMed_21979375_A2 | Up | 0.1417697900 |
| GSE35957 | Up | 0.0277447181 |
| GSE36640 | Up | 0.0086520933 |
| GSE54402 | Up | 0.1938178891 |
| GSE9593 | Down | -0.0411146453 |
| GSE43922 | Up | 0.1843410959 |
| GSE24585 | Up | 0.3196244184 |
| GSE37065 | Up | 0.0319305493 |
| GSE28863_A1 | Down | -0.1238063215 |
| GSE28863_A2 | Down | -0.1700923217 |
| GSE28863_A3 | Up | 0.4947974173 |
| GSE28863_A4 | Up | 0.0030895531 |
| GSE48662 | Up | 0.1199232840 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT019080 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051440 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
