HCSGD entry for FOXP3

1. General information

Official gene symbolFOXP3
Entrez ID50943
Gene full nameforkhead box P3
Other gene symbolsAIID DIETER IPEX PIDX XPID
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001782B cell homeostasisIBAbiological_process
GO:0001816Cytokine productionIEAbiological_process
GO:0002053Positive regulation of mesenchymal cell proliferationIBAbiological_process
GO:0002262Myeloid cell homeostasisIBAbiological_process
GO:0002329Pre-B cell differentiationIBAbiological_process
GO:0002361CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiationIEAbiological_process
GO:0002456T cell mediated immunityIEAbiological_process
GO:0002513Tolerance induction to self antigenIBAbiological_process
GO:0002639Positive regulation of immunoglobulin productionIBAbiological_process
GO:0002669Positive regulation of T cell anergyIBAbiological_process
GO:0002677Negative regulation of chronic inflammatory responseIBAbiological_process
GO:0002725Negative regulation of T cell cytokine productionIDAbiological_process
GO:0002851Positive regulation of peripheral T cell tolerance inductionIBAbiological_process
GO:0003682Chromatin bindingIBAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDA NASmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0003714Transcription corepressor activityIBAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA NAScellular_component
GO:0005737CytoplasmIEA NAScellular_component
GO:0006338Chromatin remodelingNASbiological_process
GO:0006355Regulation of transcription, DNA-templatedNASbiological_process
GO:0007389Pattern specification processIBAbiological_process
GO:0007519Skeletal muscle tissue developmentIBAbiological_process
GO:0008285Negative regulation of cell proliferationIDAbiological_process
GO:0008301DNA binding, bendingIBAmolecular_function
GO:0009615Response to virusIEPbiological_process
GO:0009790Embryo developmentIBAbiological_process
GO:0030324Lung developmentIBAbiological_process
GO:0031064Negative regulation of histone deacetylationIGIbiological_process
GO:0032088Negative regulation of NF-kappaB transcription factor activityIDAbiological_process
GO:0032689Negative regulation of interferon-gamma productionIDAbiological_process
GO:0032693Negative regulation of interleukin-10 productionIDAbiological_process
GO:0032703Negative regulation of interleukin-2 productionIDAbiological_process
GO:0032713Negative regulation of interleukin-4 productionIDAbiological_process
GO:0032714Negative regulation of interleukin-5 productionIBAbiological_process
GO:0032715Negative regulation of interleukin-6 productionIBAbiological_process
GO:0032720Negative regulation of tumor necrosis factor productionIBAbiological_process
GO:0032753Positive regulation of interleukin-4 productionIEAbiological_process
GO:0032792Negative regulation of CREB transcription factor activityIDAbiological_process
GO:0032831Positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiationIBAbiological_process
GO:0032914Positive regulation of transforming growth factor beta1 productionIBAbiological_process
GO:0033092Positive regulation of immature T cell proliferation in thymusIBAbiological_process
GO:0033152Immunoglobulin V(D)J recombinationIBAbiological_process
GO:0035035Histone acetyltransferase bindingIPImolecular_function
GO:0035066Positive regulation of histone acetylationIMPbiological_process
GO:0035067Negative regulation of histone acetylationIBAbiological_process
GO:0042036Negative regulation of cytokine biosynthetic processIDAbiological_process
GO:0042110T cell activationIDAbiological_process
GO:0042130Negative regulation of T cell proliferationIDAbiological_process
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0042826Histone deacetylase bindingIPImolecular_function
GO:0043029T cell homeostasisNASbiological_process
GO:0043234Protein complexNAScellular_component
GO:0043433Negative regulation of sequence-specific DNA binding transcription factor activityIDAbiological_process
GO:0043565Sequence-specific DNA bindingIDAmolecular_function
GO:0045077Negative regulation of interferon-gamma biosynthetic processIBAbiological_process
GO:0045085Negative regulation of interleukin-2 biosynthetic processIMPbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDA IMP ISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIMPbiological_process
GO:0046007Negative regulation of activated T cell proliferationNASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0046982Protein heterodimerization activityIBAmolecular_function
GO:0048294Negative regulation of isotype switching to IgE isotypesIBAbiological_process
GO:0048302Regulation of isotype switching to IgG isotypesIBAbiological_process
GO:0048745Smooth muscle tissue developmentIBAbiological_process
GO:0050679Positive regulation of epithelial cell proliferationIBAbiological_process
GO:0050710Negative regulation of cytokine secretionIDAbiological_process
GO:0050777Negative regulation of immune responseIDAbiological_process
GO:0050852T cell receptor signaling pathwayIBAbiological_process
GO:0051059NF-kappaB bindingNASmolecular_function
GO:0051525NFAT protein bindingIPImolecular_function
GO:0055007Cardiac muscle cell differentiationIBAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.76067309370.87606462140.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0155269499
GSE13712_SHEARDown-0.0346890558
GSE13712_STATICDown-0.0414610283
GSE19018Up0.0174183515
GSE19899_A1Up0.0290615811
GSE19899_A2Up0.0287449011
PubMed_21979375_A1Up0.1139102027
PubMed_21979375_A2Down-0.0951531443
GSE35957Up0.0377816758
GSE36640Down-0.0046763074
GSE54402Up0.0689336348
GSE9593Down-0.0054239941
GSE43922Up0.0374920378
GSE24585Down-0.0214611018
GSE37065Down-0.0720415372
GSE28863_A1Up0.0907708983
GSE28863_A2Down-0.0073110011
GSE28863_A3Up0.3292483854
GSE28863_A4Up0.0469479079
GSE48662Down-0.0246179709

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-31-5pMIMAT0000089MIRT001180qRT-PCR//Luciferase reporter assay//Western blotFunctional MTI19408243
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27354409An increase of IL-2 production was observed in these senescent CD4+ T cells and was driven by a markedly reduced frequency of Foxp3+ regulatory T (Treg) cells and increased number of Foxp3- effector T (Teff) cells upon manipulating the DeltaNp63-miR-181a-Sirt1 pathway
27238838Foxp3 is a key downstream regulator of p53-mediated cellular senescence
27238838Here, we report a novel function of the forkhead transcription factor Foxp3, which is a key player in mediating T-cell inhibitory functions, in p53-mediated cellular senescence
27238838The overexpression of Foxp3 in mouse embryonic fibroblasts (MEFs) accelerates senescence, whereas Foxp3 knockdown leads to escape from p53-mediated senescence in p53-expressing MEFs
27238838Consistent with these results, Foxp3 expression resulted in the induction of senescence in epithelial cancer cells, including MCF7 and HCT116 cells
27238838Foxp3 overexpression also increased the intracellular levels of reactive oxygen species (ROS)
27238838Furthermore, the elevated ROS levels that accompanied Foxp3 overexpression were paralleled by an increase in p21 expression
27238838Knockdown of p21 in Foxp3-expressing MEFs abrogated the Foxp3-dependent increase in ROS levels, indicating that Foxp3 acts through the induction of p21 and the subsequent ROS elevation to trigger senescence
27238838Collectively, these results suggest that Foxp3 is a downstream target of p53 that is sufficient to induce p21 expression, ROS production and p53-mediated senescence
23824593Extrathymic induction of Foxp3(+) regulatory T cells declines with age in a T-cell intrinsic manner
23824593Extrathymically induced Foxp3(+) regulatory T (Treg) cells contribute to the pool of Treg cells and are implicated in the maintenance of immune tolerance at environmental interfaces
23824593We report here that steady-state induction of Foxp3 is impaired in aged T cells in vivo
23824593Importantly, they also revealed that this impairment of Foxp3 induction is unrelated to known age-related T-cell defects, such as IL-2 secretion impairment, accumulation of activated T-cell populations, or narrowing of the T-cell repertoire
23824593Finally, a loss of extrathymic induction of Foxp3 and tolerance to minor-mismatched skin graft were observed in aged mice treated by nondepleting anti-CD4 antibody
21300823These subsets exhibited differences in suppressive capacity, ability to secrete IL-10 and IL-17, Foxp3 gene methylation, cellular senescence, and frequency in neonatal and adult blood
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