HCSGD entry for PC
1. General information
| Official gene symbol | PC |
|---|---|
| Entrez ID | 5091 |
| Gene full name | pyruvate carboxylase |
| Other gene symbols | PCB |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0004075 | Biotin carboxylase activity | IEA | molecular_function |
| GO:0004736 | Pyruvate carboxylase activity | IEA TAS | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | IEA | cellular_component |
| GO:0005759 | Mitochondrial matrix | TAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005975 | Carbohydrate metabolic process | TAS | biological_process |
| GO:0006006 | Glucose metabolic process | TAS | biological_process |
| GO:0006090 | Pyruvate metabolic process | IEA | biological_process |
| GO:0006094 | Gluconeogenesis | IEA TAS | biological_process |
| GO:0006107 | Oxaloacetate metabolic process | IEA | biological_process |
| GO:0006629 | Lipid metabolic process | IEA | biological_process |
| GO:0006766 | Vitamin metabolic process | TAS | biological_process |
| GO:0006767 | Water-soluble vitamin metabolic process | TAS | biological_process |
| GO:0006768 | Biotin metabolic process | TAS | biological_process |
| GO:0009374 | Biotin binding | IEA | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4919173246 | 0.0542538619 | 0.9999902473 | 0.4386963759 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0367819524 |
| GSE13712_SHEAR | Up | 0.3397705698 |
| GSE13712_STATIC | Up | 0.0663267988 |
| GSE19018 | Up | 0.1105528971 |
| GSE19899_A1 | Down | -0.2473439469 |
| GSE19899_A2 | Down | -0.8915575270 |
| PubMed_21979375_A1 | Down | -0.0271331094 |
| PubMed_21979375_A2 | Down | -0.1369750201 |
| GSE35957 | Down | -0.6903273538 |
| GSE36640 | Up | 0.0090651393 |
| GSE54402 | Down | -0.7747617315 |
| GSE9593 | Down | -0.8330105520 |
| GSE43922 | Down | -0.0897031128 |
| GSE24585 | Up | 0.5761934655 |
| GSE37065 | Down | -0.2989409800 |
| GSE28863_A1 | Up | 0.0133886624 |
| GSE28863_A2 | Down | -0.3479239628 |
| GSE28863_A3 | Up | 0.1422245909 |
| GSE28863_A4 | Up | 0.0401473265 |
| GSE48662 | Up | 0.9030551124 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL | DB07497 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017539 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-125a-5p | MIMAT0000443 | MIRT045724 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 8903398 | The change in the rate of gluconeogenesis was not accompanied by changes in any of the following parameters: phosphoenolpyruvate carboxykinase or pyruvate carboxylase activities or mitochondrial ATP/ADP or cytosolic NADH/NAD+ ratios |
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