HCSGD entry for PBX2
1. General information
| Official gene symbol | PBX2 |
|---|---|
| Entrez ID | 5089 |
| Gene full name | pre-B-cell leukemia homeobox 2 |
| Other gene symbols | G17 HOX12 PBX2MHC |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005667 | Transcription factor complex | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0008134 | Transcription factor binding | IPI | molecular_function |
| GO:0009954 | Proximal/distal pattern formation | IEA | biological_process |
| GO:0030326 | Embryonic limb morphogenesis | IEA | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9612041982 | 0.1065841153 | 0.9999902473 | 0.6250892380 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0067094038 |
| GSE13712_SHEAR | Up | 0.1071033276 |
| GSE13712_STATIC | Up | 0.1185371344 |
| GSE19018 | Up | 0.0472966633 |
| GSE19899_A1 | Up | 0.0399126860 |
| GSE19899_A2 | Up | 0.1029223908 |
| PubMed_21979375_A1 | Down | -0.2682334367 |
| PubMed_21979375_A2 | Down | -0.3001743066 |
| GSE35957 | Down | -0.3567698670 |
| GSE36640 | Down | -0.3130723992 |
| GSE54402 | Up | 0.0007324809 |
| GSE9593 | Down | -0.0334021903 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Down | -0.0777739545 |
| GSE28863_A2 | Down | -0.3429359746 |
| GSE28863_A3 | Down | -0.3509766873 |
| GSE28863_A4 | Down | -0.2470787917 |
| GSE48662 | Down | -0.3135337758 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-760 | MIMAT0004957 | MIRT036763 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-181d-5p | MIMAT0002821 | MIRT041169 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-326 | MIMAT0000756 | MIRT043641 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-185-5p | MIMAT0000455 | MIRT045365 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046804 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-197-3p | MIMAT0000227 | MIRT048088 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049093 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
