HCSGD entry for PBX1

1. General information

Official gene symbolPBX1
Entrez ID5087
Gene full namepre-B-cell leukemia homeobox 1
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIEAmolecular_function
GO:0001658Branching involved in ureteric bud morphogenesisIEAbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEA NASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005667Transcription factor complexIEAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDA IEAcellular_component
GO:0006694Steroid biosynthetic processIEAbiological_process
GO:0007548Sex differentiationIEAbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0009887Organ morphogenesisIEAbiological_process
GO:0009952Anterior/posterior pattern specificationIEAbiological_process
GO:0009954Proximal/distal pattern formationIEAbiological_process
GO:0010971Positive regulation of G2/M transition of mitotic cell cycleIEAbiological_process
GO:0030278Regulation of ossificationIEAbiological_process
GO:0030325Adrenal gland developmentIEAbiological_process
GO:0030326Embryonic limb morphogenesisIEAbiological_process
GO:0035162Embryonic hemopoiesisIEAbiological_process
GO:0043433Negative regulation of sequence-specific DNA binding transcription factor activityIDAbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0045665Negative regulation of neuron differentiationIEAbiological_process
GO:0046982Protein heterodimerization activityIEAmolecular_function
GO:0048536Spleen developmentIEAbiological_process
GO:0048538Thymus developmentIEAbiological_process
GO:0048706Embryonic skeletal system developmentIEAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.97637269480.00002949360.99999024730.0094780488

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3436972798
GSE13712_SHEARDown-3.1411526290
GSE13712_STATICDown-2.5365970512
GSE19018Down-0.8833721561
GSE19899_A1Down-1.4237727195
GSE19899_A2Down-2.8650580548
PubMed_21979375_A1Down-3.9111072663
PubMed_21979375_A2Down-2.4489676287
GSE35957Up0.6333509540
GSE36640Down-1.5797246576
GSE54402Down-2.2029017711
GSE9593Down-0.1441710747
GSE43922Down-1.8179045366
GSE24585Down-0.4530336911
GSE37065Up0.4815147039
GSE28863_A1Up0.4463166759
GSE28863_A2Up0.1313176021
GSE28863_A3Down-0.0702969186
GSE28863_A4Down-0.3973390912
GSE48662Down-0.1656788425

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT022992Proteomics;MicroarrayFunctional MTI (Weak)18668037
hsa-miR-21-5pMIMAT0000076MIRT030981MicroarrayFunctional MTI (Weak)18591254
hsa-miR-877-3pMIMAT0004950MIRT037024CLASHFunctional MTI (Weak)23622248
hsa-miR-149-5pMIMAT0000450MIRT045499CLASHFunctional MTI (Weak)23622248
Entries Per Page
Displaying Page of
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.