HCSGD entry for PAX2

1. General information

Official gene symbolPAX2
Entrez ID5076
Gene full namepaired box 2
Other gene symbolsPAPRS
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0000987Core promoter proximal region sequence-specific DNA bindingIDA IEAmolecular_function
GO:0001655Urogenital system developmentISSbiological_process
GO:0001658Branching involved in ureteric bud morphogenesisIEA IEP ISSbiological_process
GO:0001709Cell fate determinationIEA ISSbiological_process
GO:0001823Mesonephros developmentISSbiological_process
GO:0001843Neural tube closureIEA ISSbiological_process
GO:0002072Optic cup morphogenesis involved in camera-type eye developmentIEA ISSbiological_process
GO:0003337Mesenchymal to epithelial transition involved in metanephros morphogenesisIEA ISSbiological_process
GO:0003406Retinal pigment epithelium developmentIEA ISSbiological_process
GO:0003677DNA bindingIEA ISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005764LysosomeIEAcellular_component
GO:0005815Microtubule organizing centerIDAcellular_component
GO:0006351Transcription, DNA-templatedIEA ISSbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0006366Transcription from RNA polymerase II promoterTASbiological_process
GO:0007275Multicellular organismal developmentIEAbiological_process
GO:0007409AxonogenesisTASbiological_process
GO:0007501Mesodermal cell fate specificationIEA ISSbiological_process
GO:0007568AgingIEAbiological_process
GO:0007601Visual perceptionTASbiological_process
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0010001Glial cell differentiationIEA ISSbiological_process
GO:0016175Superoxide-generating NADPH oxidase activityIEA ISSmolecular_function
GO:0021554Optic nerve developmentISSbiological_process
GO:0021631Optic nerve morphogenesisISSbiological_process
GO:0021633Optic nerve structural organizationIEA ISSbiological_process
GO:0021650Vestibulocochlear nerve formationIEA ISSbiological_process
GO:0031016Pancreas developmentIEAbiological_process
GO:0031667Response to nutrient levelsIEAbiological_process
GO:0032993Protein-DNA complexIEA ISScellular_component
GO:0034451Centriolar satelliteIDAcellular_component
GO:0035566Regulation of metanephros sizeIEA IMPbiological_process
GO:0035799Ureter maturationIEA ISSbiological_process
GO:0039003Pronephric field specificationIEA ISSbiological_process
GO:0042472Inner ear morphogenesisISSbiological_process
GO:0043010Camera-type eye developmentISSbiological_process
GO:0043066Negative regulation of apoptotic processIDA IMPbiological_process
GO:0043069Negative regulation of programmed cell deathISSbiological_process
GO:0043154Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processIDAbiological_process
GO:0043234Protein complexIEA ISScellular_component
GO:0043491Protein kinase B signalingIEA ISSbiological_process
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045892Negative regulation of transcription, DNA-templatedIMPbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDA IEAbiological_process
GO:0045918Negative regulation of cytolysisIMPbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA ISSbiological_process
GO:0048793Pronephros developmentISSbiological_process
GO:0048854Brain morphogenesisIEA ISSbiological_process
GO:0048863Stem cell differentiationISSbiological_process
GO:0050679Positive regulation of epithelial cell proliferationIDAbiological_process
GO:0055114Oxidation-reduction processISSbiological_process
GO:0060231Mesenchymal to epithelial transitionISSbiological_process
GO:0061205Paramesonephric duct developmentIEAbiological_process
GO:0061360Optic chiasma developmentIEA ISSbiological_process
GO:0070301Cellular response to hydrogen peroxideIEA ISSbiological_process
GO:0070742C2H2 zinc finger domain bindingIEAmolecular_function
GO:0071260Cellular response to mechanical stimulusIEAbiological_process
GO:0071300Cellular response to retinoic acidIEA ISSbiological_process
GO:0071333Cellular response to glucose stimulusIEA ISSbiological_process
GO:0071364Cellular response to epidermal growth factor stimulusIEAbiological_process
GO:0072075Metanephric mesenchyme developmentISSbiological_process
GO:0072108Positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesisIEA ISSbiological_process
GO:0072162Metanephric mesenchymal cell differentiationIEA ISSbiological_process
GO:0072172Mesonephric tubule formationIEAbiological_process
GO:0072177Mesonephric duct developmentIEAbiological_process
GO:0072179Nephric duct formationIEA ISSbiological_process
GO:0072189Ureter developmentISSbiological_process
GO:0072197Ureter morphogenesisIEAbiological_process
GO:0072205Metanephric collecting duct developmentIEA ISSbiological_process
GO:0072207Metanephric epithelium developmentIEPbiological_process
GO:0072221Metanephric distal convoluted tubule developmentIEA ISSbiological_process
GO:0072289Metanephric nephron tubule formationIEA ISSbiological_process
GO:0072300Positive regulation of metanephric glomerulus developmentIEA ISSbiological_process
GO:0072305Negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesisIEA ISSbiological_process
GO:0072307Regulation of metanephric nephron tubule epithelial cell differentiationIEA ISSbiological_process
GO:0072593Reactive oxygen species metabolic processIEA ISSbiological_process
GO:0090102Cochlea developmentISSbiological_process
GO:0090103Cochlea morphogenesisIEA ISSbiological_process
GO:0090190Positive regulation of branching involved in ureteric bud morphogenesisIEA ISSbiological_process
GO:1900212Negative regulation of mesenchymal cell apoptotic process involved in metanephros developmentISSbiological_process
GO:1900215Negative regulation of apoptotic process involved in metanephric collecting duct developmentIEA ISSbiological_process
GO:1900218Negative regulation of apoptotic process involved in metanephric nephron tubule developmentIEA ISSbiological_process
GO:2000378Negative regulation of reactive oxygen species metabolic processIDAbiological_process
GO:2000594Positive regulation of metanephric DCT cell differentiationIEA ISSbiological_process
GO:2000597Positive regulation of optic nerve formationIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.57555211430.83502386690.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0121955187
GSE13712_SHEARUp0.0686504225
GSE13712_STATICUp0.1375301240
GSE19018Down-0.0536459457
GSE19899_A1Up0.0624317036
GSE19899_A2Up0.1601444524
PubMed_21979375_A1Down-0.0650905755
PubMed_21979375_A2Up0.1210813448
GSE35957Up0.1311812501
GSE36640Up0.0952731802
GSE54402Down-0.0107212600
GSE9593Up0.0359295798
GSE43922Up0.0486124599
GSE24585Down-0.6184378027
GSE37065Up0.0446922810
GSE28863_A1Down-0.0623095028
GSE28863_A2Down-0.0083125382
GSE28863_A3Up0.3095663615
GSE28863_A4Up0.1152784645
GSE48662Up0.0206794274

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-423-5pMIMAT0004748MIRT038163CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.