HCSGD entry for PARN

1. General information

Official gene symbolPARN
Entrez ID5073
Gene full namepoly(A)-specific ribonuclease
Other gene symbolsDAN
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000166Nucleotide bindingIEAmolecular_function
GO:0000184Nuclear-transcribed mRNA catabolic process, nonsense-mediated decayIMPbiological_process
GO:0000288Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decayTASbiological_process
GO:0000289Nuclear-transcribed mRNA poly(A) tail shorteningTASbiological_process
GO:0003676Nucleic acid bindingIEAmolecular_function
GO:0003723RNA bindingIEAmolecular_function
GO:0003730MRNA 3'-UTR bindingTASmolecular_function
GO:0004518Nuclease activityTASmolecular_function
GO:0004535Poly(A)-specific ribonuclease activityIEA TASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEA TAScellular_component
GO:0005730NucleolusIEAcellular_component
GO:0005737CytoplasmIEA TAScellular_component
GO:0005829CytosolTAScellular_component
GO:0006402MRNA catabolic processIEAbiological_process
GO:0007292Female gamete generationTASbiological_process
GO:0009451RNA modificationTASbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0019901Protein kinase bindingIPImolecular_function
GO:0046872Metal ion bindingIEAmolecular_function
GO:0090305Nucleic acid phosphodiester bond hydrolysisTASbiological_process
GO:0090501RNA phosphodiester bond hydrolysisTASbiological_process
GO:0090503RNA phosphodiester bond hydrolysis, exonucleolyticTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.83596242160.07745435960.99999024730.5266536296

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3297076547
GSE13712_SHEARDown-0.5273262506
GSE13712_STATICUp0.1696680536
GSE19018Up0.0834848598
GSE19899_A1Down-0.2273215568
GSE19899_A2Down-0.2740127882
PubMed_21979375_A1Up0.2323148545
PubMed_21979375_A2Down-0.4648689168
GSE35957Down-0.4506867493
GSE36640Down-0.6553799494
GSE54402Down-0.0660867430
GSE9593Up0.0895774029
GSE43922Down-0.0959571611
GSE24585Down-0.3441962902
GSE37065Down-0.1331873813
GSE28863_A1Up0.1909440628
GSE28863_A2Up0.2391012974
GSE28863_A3Down-0.6533072509
GSE28863_A4Up0.1397269157
GSE48662Up0.0900509511

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT022591Proteomics;MicroarrayFunctional MTI (Weak)18668037
hsa-miR-215-5pMIMAT0000272MIRT024604MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026386MicroarrayFunctional MTI (Weak)19074876
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.