HCSGD entry for PARK2

1. General information

Official gene symbolPARK2
Entrez ID5071
Gene full nameparkinson protein 2, E3 ubiquitin protein ligase (parkin)
Other gene symbolsAR-JP LPRS2 PDJ PRKN
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000209Protein polyubiquitinationIDAbiological_process
GO:0000422Mitochondrion degradationIMPbiological_process
GO:0001933Negative regulation of protein phosphorylationIDAbiological_process
GO:0004842Ubiquitin-protein ligase activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005739MitochondrionIDA IEA IMPcellular_component
GO:0005783Endoplasmic reticulumIEAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005829CytosolIDA IEAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0006511Ubiquitin-dependent protein catabolic processIDAbiological_process
GO:0006513Protein monoubiquitinationIDAbiological_process
GO:0007417Central nervous system developmentTASbiological_process
GO:0008219Cell deathIDAbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0010506Regulation of autophagyIDAbiological_process
GO:0016235AggresomeIDAcellular_component
GO:0019900Kinase bindingIPImolecular_function
GO:0019901Protein kinase bindingIPImolecular_function
GO:0030165PDZ domain bindingIPImolecular_function
GO:0031625Ubiquitin protein ligase bindingIPImolecular_function
GO:0032232Negative regulation of actin filament bundle assemblyIDAbiological_process
GO:0042787Protein ubiquitination involved in ubiquitin-dependent protein catabolic processIDAbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIDAbiological_process
GO:0043524Negative regulation of neuron apoptotic processIDAbiological_process
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0051087Chaperone bindingIPImolecular_function
GO:0051865Protein autoubiquitinationIDAbiological_process
GO:0060548Negative regulation of cell deathIDAbiological_process
GO:0070534Protein K63-linked ubiquitinationIDAbiological_process
GO:0070842Aggresome assemblyIMPbiological_process
GO:0070936Protein K48-linked ubiquitinationIDAbiological_process
GO:0070997Neuron deathIDAbiological_process
GO:0090201Negative regulation of release of cytochrome c from mitochondriaIDAbiological_process
GO:2000377Regulation of reactive oxygen species metabolic processIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.75938754230.80767529350.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0383938793
GSE13712_SHEARDown-0.0387659459
GSE13712_STATICDown-0.0328079529
GSE19018Up0.0382199797
GSE19899_A1Up0.0652925638
GSE19899_A2Up0.0084504397
PubMed_21979375_A1Down-0.1346016271
PubMed_21979375_A2Up0.1376167686
GSE35957Up0.0362272071
GSE36640Up0.0848467389
GSE54402Up0.0242436526
GSE9593Up0.1364420960
GSE43922Up0.0114439738
GSE24585Up0.0042028385
GSE37065Down-0.1475952088
GSE28863_A1Down-0.0486526933
GSE28863_A2Up0.0186146418
GSE28863_A3Up0.1047263951
GSE28863_A4Up0.0223920213
GSE48662Up0.1931479957

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT016831MicroarrayFunctional MTI (Weak)18185580
hsa-miR-26b-5pMIMAT0000083MIRT028924MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25714760To elucidate the involvement of PINK1 and PARK2 in mitophagy, knockdown and overexpression experiments were performed
25714760PINK1 and PARK2 protein levels in lungs from patients were evaluated by means of lung homogenate and immunohistochemistry
25714760CSE-induced mitophagy was inhibited by PINK1 and PARK2 knockdown, resulting in enhanced mitochondrial ROS production and cellular senescence in HBEC
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