HCSGD entry for PAM

1. General information

Official gene symbolPAM
Entrez ID5066
Gene full namepeptidylglycine alpha-amidating monooxygenase
Other gene symbolsPAL PHM
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001519Peptide amidationIEAbiological_process
GO:0001666Response to hypoxiaIEAbiological_process
GO:0001676Long-chain fatty acid metabolic processIEAbiological_process
GO:0004504Peptidylglycine monooxygenase activityIEAmolecular_function
GO:0004598Peptidylamidoglycolate lyase activityIEAmolecular_function
GO:0005507Copper ion bindingIEAmolecular_function
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005615Extracellular spaceIEAcellular_component
GO:0005802Trans-Golgi networkIEAcellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0006357Regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0006518Peptide metabolic processIEAbiological_process
GO:0007417Central nervous system developmentIEAbiological_process
GO:0007507Heart developmentIEAbiological_process
GO:0007595LactationIEAbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0009268Response to pHIEAbiological_process
GO:0009404Toxin metabolic processIEAbiological_process
GO:0009986Cell surfaceIEAcellular_component
GO:0016020MembraneIEAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0018032Protein amidationIEAbiological_process
GO:0019901Protein kinase bindingIEAmolecular_function
GO:0022602Ovulation cycle processIEAbiological_process
GO:0030667Secretory granule membraneIEAcellular_component
GO:0031418L-ascorbic acid bindingIEAmolecular_function
GO:0032355Response to estradiolIEAbiological_process
GO:0032956Regulation of actin cytoskeleton organizationIEAbiological_process
GO:0042476OdontogenesisIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0043005Neuron projectionIEAcellular_component
GO:0043204PerikaryonIEAcellular_component
GO:0046688Response to copper ionIEAbiological_process
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
GO:0050708Regulation of protein secretionIEAbiological_process
GO:0051260Protein homooligomerizationIEAbiological_process
GO:0051384Response to glucocorticoidIEAbiological_process
GO:0060135Maternal process involved in female pregnancyIEAbiological_process
GO:0060173Limb developmentIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.15755353900.16059883740.78793037780.7737216508

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0680947263
GSE13712_SHEARDown-0.1267894092
GSE13712_STATICDown-0.1590026068
GSE19018Up1.1864790582
GSE19899_A1Down-0.2333722102
GSE19899_A2Up0.0563773222
PubMed_21979375_A1Down-0.4200601753
PubMed_21979375_A2Up0.2552175709
GSE35957Up0.3733326887
GSE36640Up0.6313294480
GSE54402Down-0.3168462147
GSE9593Up0.6479830134
GSE43922Down-0.2314215827
GSE24585Up0.0350157459
GSE37065Up0.2954325601
GSE28863_A1Up0.0729555521
GSE28863_A2Up0.6416787272
GSE28863_A3Down-0.4304205350
GSE28863_A4Down-0.5271266345
GSE48662Down-0.2710841697

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Vitamin CDB00126 NUTR00001 | APRD00084 | EXPT00568 | DB09541
N-Alpha-Acetyl-3,5-DiiodotyrosylglycineDB02598 EXPT01950
Threonine DerivativeDB04150 EXPT01952

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-125a-5pMIMAT0000443MIRT045767CLASHFunctional MTI (Weak)23622248
hsa-miR-125b-5pMIMAT0000423MIRT046087CLASHFunctional MTI (Weak)23622248
hsa-miR-30c-5pMIMAT0000244MIRT047841CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.