HCSGD entry for ARHGEF4

1. General information

Official gene symbolARHGEF4
Entrez ID50649
Gene full nameRho guanine nucleotide exchange factor (GEF) 4
Other gene symbolsASEF ASEF1 GEF4 STM6
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005085Guanyl-nucleotide exchange factor activityIMPmolecular_function
GO:0005089Rho guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005829CytosolTAScellular_component
GO:0007264Small GTPase mediated signal transductionTASbiological_process
GO:0019904Protein domain specific bindingIPImolecular_function
GO:0030032Lamellipodium assemblyIMPbiological_process
GO:0030676Rac guanyl-nucleotide exchange factor activityIMPmolecular_function
GO:0032314Regulation of Rac GTPase activityIMPbiological_process
GO:0032318Regulation of Ras GTPase activityIMPbiological_process
GO:0032319Regulation of Rho GTPase activityIMPbiological_process
GO:0032587Ruffle membraneIEAcellular_component
GO:0035556Intracellular signal transductionIEAbiological_process
GO:0043065Positive regulation of apoptotic processTASbiological_process
GO:0043087Regulation of GTPase activityIMPbiological_process
GO:0046847Filopodium assemblyIMPbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0051056Regulation of small GTPase mediated signal transductionTASbiological_process
GO:0097190Apoptotic signaling pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.80611913300.73814047340.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0752804634
GSE13712_SHEARDown-0.1663926907
GSE13712_STATICUp0.0358485442
GSE19018Down-0.1198960607
GSE19899_A1Down-0.0229337901
GSE19899_A2Up0.0079404235
PubMed_21979375_A1Up0.0298901157
PubMed_21979375_A2Up0.0278061196
GSE35957Up0.2698947746
GSE36640Down-0.0610281603
GSE54402Up0.2838267727
GSE9593Up0.1292601588
GSE43922Up0.0259440144
GSE24585Down-0.0418426640
GSE37065Down-0.0538085800
GSE28863_A1Down-0.1686935324
GSE28863_A2Down-0.0476245787
GSE28863_A3Up0.2433345474
GSE28863_A4Down-0.0201530797
GSE48662Up0.0650543195

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT016987MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.